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4 |
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33622083 | Using the CYP3A Activity Evaluation to Predict the Efficacy and Safety of Diazepam in Patients With Alcohol Withdrawal Syndrome. | 2021 Feb 24 |
3 |
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34503953 | Complex Cytochrome P450 Kinetics Due to Multisubstrate Binding and Sequential Metabolism. Part 2. Modeling of Experimental Data. | 2021 Dec |
2 |
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32446424 | High Doses of Drugs Extensively Metabolized by CYP3A4 Were Needed to Reach Therapeutic Concentrations in Two Patients Taking Inducers. | 2020 Apr - Jun |
1 |
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27231113 | Drug interaction between idelalisib and diazepam resulting in altered mental status and respiratory failure. | 2017 Sep |
2 |
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24500275 | Urinary diazepam metabolite distribution in a chronic pain population. | 2014 Apr |
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28520370 | Diazepam Therapy and CYP2C19 Genotype | 2012 |
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19898817 | Identification of a CYP3A form (CYP3A126) in fathead minnow (Pimephales promelas) and characterisation of putative CYP3A enzyme activity. | 2010 Jan |
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19905875 | Effects of organic solvents on the time-dependent inhibition of CYP3A4 by diazepam. | 2010 Jan |
4 |
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18983865 | Two compartment model of diazepam biotransformation in an organotypical culture of primary human hepatocytes. | 2009 Jan 15 |
1 |
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18076219 | Interaction profile of armodafinil with medications metabolized by cytochrome P450 enzymes 1A2, 3A4 and 2C19 in healthy subjects. | 2008 |
1 |
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18175099 | Midazolam and other benzodiazepines. | 2008 |
2 |
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18846481 | Human CYP3A4-introduced HepG2 cells: in vitro screening system of new chemicals for the evaluation of CYP3A4-inhibiting activity. | 2008 Nov |
1 |
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17284003 | Structural dynamics of the cooperative binding of organic molecules in the human cytochrome P450 3A4. | 2007 Feb 14 |
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16141545 | Contribution of human hepatic cytochrome p450 isoforms to the metabolism of psychotropic drugs. | 2005 Sep |
1 |
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12464248 | Analysis of homotropic and heterotropic cooperativity of diazepam oxidation by CYP3A4 using site-directed mutagenesis and kinetic modeling. | 2003 Jan 1 |
3 |
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24930414 | Symptomatic hypotension with venlafaxine-benzodiazepine interaction. | 2003 |
1 |
| 18 |
12228192 | Diclofenac-induced inactivation of CYP3A4 and its stimulation by quinidine. | 2002 Oct |
1 |
| 19 |
11560871 | Effects of CYP3A4 inhibition by diltiazem on pharmacokinetics and dynamics of diazepam in relation to CYP2C19 genotype status. | 2001 Oct |
5 |
| 20 |
11717184 | Multisite kinetic models for CYP3A4: simultaneous activation and inhibition of diazepam and testosterone metabolism. | 2001 Dec |
3 |
| 21 |
10659949 | Cytochrome P450 enzyme activity and protein expression in primary porcine enterocyte and hepatocyte cultures. | 2000 Jan |
1 |
| 22 |
10757990 | Amino acid 305 determines catalytic center accessibility in CYP3A4. | 2000 Apr 18 |
1 |
| 23 |
10771285 | Use of inhibitory monoclonal antibodies to assess the contribution of cytochromes P450 to human drug metabolism. | 2000 Apr 14 |
4 |
| 24 |
10821163 | Assessment of specificity of eight chemical inhibitors using cDNA-expressed cytochromes P450. | 2000 Apr |
1 |
| 25 |
10359672 | Sigmoidal kinetic model for two co-operative substrate-binding sites in a cytochrome P450 3A4 active site: an example of the metabolism of diazepam and its derivatives. | 1999 Jun 15 |
2 |
| 26 |
10418969 | Comparative effects of rifabutin and rifampicin on cytochromes P450 and UDP-glucuronosyl-transferases expression in fresh and cryopreserved human hepatocytes. | 1999 Jun 1 |
1 |
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10525096 | Role of a potent inhibitory monoclonal antibody to cytochrome P-450 3A4 in assessment of human drug metabolism. | 1999 Nov |
4 |
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9429229 | Developmental expression of CYP2C and CYP2C-dependent activities in the human liver: in-vivo/in-vitro correlation and inducibility. | 1997 Dec |
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1 |
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8923565 | Possible inhibitory effect of diazepam on the metabolism of zotepine, an antipsychotic drug. | 1996 Oct |
1 |
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8930576 | Metabolic interactions of the proton-pump inhibitors lansoprazole, omeprazole and pantoprazole with other drugs. | 1996 Oct |
1 |
| 32 |
8948091 | Human liver microsomal diazepam metabolism using cDNA-expressed cytochrome P450s: role of CYP2B6, 2C19 and the 3A subfamily. | 1996 Nov |
1 |
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7981013 | Diazepam metabolism by human liver microsomes is mediated by both S-mephenytoin hydroxylase and CYP3A isoforms. | 1994 Aug |
1 |