Title : Sigmoidal kinetic model for two co-operative substrate-binding sites in a cytochrome P450 3A4 active site: an example of the metabolism of diazepam and its derivatives.

Pub. Date : 1999 Jun 15

PMID : 10359672






2 Functional Relationships(s)
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1 Sigmoidal kinetic model for two co-operative substrate-binding sites in a cytochrome P450 3A4 active site: an example of the metabolism of diazepam and its derivatives. Diazepam cytochrome P450 family 3 subfamily A member 4 Homo sapiens
2 In the present study, diazepam, temazepam and nordiazepam were employed as substrates of CYP3A4 to propose a kinetic model. Diazepam cytochrome P450 family 3 subfamily A member 4 Homo sapiens