Title : Assessment of specificity of eight chemical inhibitors using cDNA-expressed cytochromes P450.

Pub. Date : 2000 Apr

PMID : 10821163






1 Functional Relationships(s)
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1 Ketoconazole exhibited potent inhibition of both CYP3A4-catalysed metabolism of phenanthrene, testosterone, diazepam (IC50 = 0.03-0.5 microM) and CYP1A1-catalysed deethylation of 7-ethoxycoumarin (0.33 microM). Diazepam cytochrome P450 family 3 subfamily A member 4 Homo sapiens