Title : Contribution of human hepatic cytochrome p450 isoforms to the metabolism of psychotropic drugs.

Pub. Date : 2005 Sep

PMID : 16141545






1 Functional Relationships(s)
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1 In addition, the metabolic activities of diazepam, clotiazepam, and etizolam in human liver microsomes were inhibited by 2.5 microM ketoconazole, a CYP3A4 inhibitor, by 97.5%, 65.1%, and 83.5%, respectively, and the imipramine metabolism was not detected after the addition of 1 or 10 microM quinidine, a CYP2D6 inhibitor. Diazepam cytochrome P450 family 3 subfamily A member 4 Homo sapiens