Tamoxifen

mitogen-activated protein kinase 1 ; Homo sapiens







44 Article(s)
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1 35110502 RSK-Mediated Non-canonical Activation of EphA2 by Tamoxifen. 2022 1
2 33861751 CSNK1G2 differently sensitizes tamoxifen-induced decrease in PI3K/AKT/mTOR/S6K and ERK signaling according to the estrogen receptor existence in breast cancer cells. 2021 5
3 33950995 Bacterial extracellular vesicles affect endocrine therapy in MCF7 cells. 2021 May 7 1
4 34182538 GPR30-mediated HMGB1 upregulation in CAFs induces autophagy and tamoxifen resistance in ERα-positive breast cancer cells. 2021 Jun 28 2
5 34209871 NR4A1 Regulates Tamoxifen Resistance by Suppressing ERK Signaling in ER-Positive Breast Cancer. 2021 Jun 29 5
6 34370280 PI3K/AKT and MAPK1 molecular changes preceding matrix metallopeptidases overexpression during tamoxifen-resistance development are correlated to poor prognosis in breast cancer patients. 2021 Nov 5
7 32435229 IGFBP-1 Expression Promotes Tamoxifen Resistance in Breast Cancer Cells via Erk Pathway Activation. 2020 2
8 33177647 Coffee decoction enhances tamoxifen proapoptotic activity on MCF-7 cells. 2020 Nov 11 1
9 30795784 Aberrant fatty acid profile and FFAR4 signaling confer endocrine resistance in breast cancer. 2019 Feb 22 1
10 28988130 KLF4 overcomes tamoxifen resistance by suppressing MAPK signaling pathway and predicts good prognosis in breast cancer. 2018 Jan 2
11 28231748 Aloe-Emodin Enhances Tamoxifen Cytotoxicity by Suppressing Ras/ERK and PI3K/mTOR in Breast Cancer Cells. 2017 2
12 28423577 The cyclin-like protein, SPY1, regulates the ERα and ERK1/2 pathways promoting tamoxifen resistance. 2017 Apr 4 1
13 28902352 GPER promotes tamoxifen-resistance in ER+ breast cancer cells by reduced Bim proteins through MAPK/Erk-TRIM2 signaling axis. 2017 Oct 1
14 26780941 MEK activity controls IL-8 expression in tamoxifen-resistant MCF-7 breast cancer cells. 2016 Apr 1
15 27507046 RAD51 inhibition in triple negative breast cancer cells is challenged by compensatory survival signaling and requires rational combination therapy. 2016 Sep 13 1
16 27519631 Tamoxifen has a proliferative effect in endometrial carcinoma mediated via the GPER/EGFR/ERK/cyclin D1 pathway: A retrospective study and an in vitro study. 2016 Dec 5 1
17 25430564 PKC/MEK inhibitors suppress oxaliplatin-induced neuropathy and potentiate the antitumor effects. 2015 Jul 1 1
18 24407515 Inhibition of GSK-3β activity can result in drug and hormonal resistance and alter sensitivity to targeted therapy in MCF-7 breast cancer cells. 2014 1
19 24481325 GPER-mediated proliferation and estradiol production in breast cancer-associated fibroblasts. 2014 Apr 1
20 24658355 Functional analysis of MKP-1 and MKP-2 in breast cancer tamoxifen sensitivity. 2014 Feb 28 2
21 24684682 ERK/MAPK regulates ERRγ expression, transcriptional activity and receptor-mediated tamoxifen resistance in ER+ breast cancer. 2014 May 1
22 24916398 Snail and Slug mediate tamoxifen resistance in breast cancer cells through activation of EGFR-ERK independent of epithelial-mesenchymal transition. 2014 Aug 1
23 23609470 Estrogen receptor α is the major driving factor for growth in tamoxifen-resistant breast cancer and supported by HER/ERK signaling. 2013 May 4
24 21863258 Alteration of Y-box binding protein-1 expression modifies the response to endocrine therapy in estrogen receptor-positive breast cancer. 2012 May 1
25 22427054 Role of PKC-ERK signaling in tamoxifen-induced apoptosis and tamoxifen resistance in human breast cancer cells. 2012 Jun 10
26 23029174 Low ERK phosphorylation in cancer-associated fibroblasts is associated with tamoxifen resistance in pre-menopausal breast cancer. 2012 4
27 21044952 Integrated quantitative analysis of the phosphoproteome and transcriptome in tamoxifen-resistant breast cancer. 2011 Jan 7 1
28 21175263 Ubiquitin ligase c-Cbl is involved in tamoxifen-induced apoptosis of MCF-7 cells by downregulating the survival signals. 2011 Jun 2
29 21573702 PI3-kinase/p38 kinase-dependent E2F1 activation is critical for Pin1 induction in tamoxifen-resistant breast cancer cells. 2011 Jul 1
30 21595894 Elevated insulin-like growth factor 1 receptor signaling induces antiestrogen resistance through the MAPK/ERK and PI3K/Akt signaling routes. 2011 May 19 2
31 21869603 Involvement of Akt and mTOR in chemotherapeutic- and hormonal-based drug resistance and response to radiation in breast cancer cells. 2011 Sep 1 1
32 21881167 Cooperative effects of Akt-1 and Raf-1 on the induction of cellular senescence in doxorubicin or tamoxifen treated breast cancer cells. 2011 Aug 1
33 19288272 Growth of hormone-dependent MCF-7 breast cancer cells is promoted by constitutive caveolin-1 whose expression is lost in an EGF-R-mediated manner during development of tamoxifen resistance. 2010 Feb 1
34 20524045 Zinc(II) ion mediates tamoxifen-induced autophagy and cell death in MCF-7 breast cancer cell line. 2010 Dec 2
35 20689759 Ron receptor tyrosine kinase activation confers resistance to tamoxifen in breast cancer cell lines. 2010 Aug 1
36 19002577 Tamoxifen and ICI 182,780 increase Bcl-2 levels and inhibit growth of breast carcinoma cells by modulating PI3K/AKT, ERK and IGF-1R pathways independent of ERalpha. 2009 Dec 1
37 18406603 The ins and outs of GPR30: a transmembrane estrogen receptor. 2008 Apr 1
38 17264668 Is ERK activation a good biomarker for estradiol and tamoxifen effects? 2007 Jan 1
39 17355262 Critical role of estrogen receptor on anoikis and invasion of squamous cell carcinoma. 2007 May 2
40 17685427 Sp3-mediated VEGF regulation is dependent on phosphorylation by extra-cellular signals regulated kinases (Erk). 2007 Nov 1
41 15806151 ERK phosphorylation is linked to VEGFR2 expression and Ets-2 phosphorylation in breast cancer and is associated with tamoxifen treatment resistance and small tumours with good prognosis. 2005 Jun 23 1
42 14645110 Tamoxifen inhibits cell proliferation via mitogen-activated protein kinase cascades in human ovarian cancer cell lines in a manner not dependent on the expression of estrogen receptor or the sensitivity to cisplatin. 2004 Mar 3
43 9090707 Activation of signal transduction kinases by tamoxifen. 1997 Feb 7
44 9372245 CGP 41251 and tamoxifen selectively inhibit mitogen-activated protein kinase activation and c-Fos phosphoprotein induction by substance P in human astrocytoma cells. 1997 Nov 1