Pub. Date : 1997 Feb
PMID : 9090707
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | PURPOSE: To study the signal transduction mechanisms of tamoxifen via the activation of MAPKs, JNK and ERK in order to understand its regulation of gene expression. | Tamoxifen | mitogen-activated protein kinase 1 | Homo sapiens |
| 2 | METHODS: The effects of tamoxifen (TAM) on the activation of serine/threonine mitogen-activated protein kinase (MAPK, p42/ERK2) and the stress-activated protein kinases (p46 SAPK or c-Jun N-terminal kinase, JNK1) were evaluated using a human cervical epitheloid carcinoma HeLa cell line. | Tamoxifen | mitogen-activated protein kinase 1 | Homo sapiens |
| 3 | METHODS: The effects of tamoxifen (TAM) on the activation of serine/threonine mitogen-activated protein kinase (MAPK, p42/ERK2) and the stress-activated protein kinases (p46 SAPK or c-Jun N-terminal kinase, JNK1) were evaluated using a human cervical epitheloid carcinoma HeLa cell line. | Tamoxifen | mitogen-activated protein kinase 1 | Homo sapiens |
| 4 | METHODS: The effects of tamoxifen (TAM) on the activation of serine/threonine mitogen-activated protein kinase (MAPK, p42/ERK2) and the stress-activated protein kinases (p46 SAPK or c-Jun N-terminal kinase, JNK1) were evaluated using a human cervical epitheloid carcinoma HeLa cell line. | Tamoxifen | mitogen-activated protein kinase 1 | Homo sapiens |
| 5 | RESULTS: TAM activated both JNK1 and ERK2 activities in a time- and dose-dependent manner in HeLa cells. | Tamoxifen | mitogen-activated protein kinase 1 | Homo sapiens |
| 6 | CONCLUSIONS: These studies show that TAM activates the signal transduction kinases, JNK1 and ERK2, which may play important roles in the regulation of gene expression by TAM. | Tamoxifen | mitogen-activated protein kinase 1 | Homo sapiens |
| 7 | CONCLUSIONS: These studies show that TAM activates the signal transduction kinases, JNK1 and ERK2, which may play important roles in the regulation of gene expression by TAM. | Tamoxifen | mitogen-activated protein kinase 1 | Homo sapiens |