Title : CGP 41251 and tamoxifen selectively inhibit mitogen-activated protein kinase activation and c-Fos phosphoprotein induction by substance P in human astrocytoma cells.

Pub. Date : 1997 Nov

PMID : 9372245






1 Functional Relationships(s)
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Protein Name
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1 Pretreatment of the cells with PKC inhibitors, CGP 41251 or tamoxifen, inhibited tyrosine phosphorylation of Erk1 and Erk2 MAP kinases induced by low concentrations of SP or TPA and significantly attenuated phosphorylation at high concentrations of SP or TPA. Tamoxifen mitogen-activated protein kinase 1 Homo sapiens