Title : KLF4 overcomes tamoxifen resistance by suppressing MAPK signaling pathway and predicts good prognosis in breast cancer.

Pub. Date : 2018 Jan

PMID : 28988130






2 Functional Relationships(s)
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1 Conversely, overexpression of KLF4 in MCF-7/TAM cells suppressed ERK and p38 signaling and resulted in increased sensitivity to TAM. Tamoxifen mitogen-activated protein kinase 1 Homo sapiens
2 Therefore, our findings suggested that KLF4 contributed to TAM sensitivity in breast cancer via phosphorylation modification of ERK and p38 signaling. Tamoxifen mitogen-activated protein kinase 1 Homo sapiens