Pub. Date : 2013 May
PMID : 23609470
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The EGFR inhibitor gefitinib and the ERK pathway inhibitor U0126 resulted in partial and preferential growth inhibition of tamoxifen-resistant cells. | Tamoxifen | mitogen-activated protein kinase 1 | Homo sapiens |
| 2 | The tamoxifen-resistant cells displayed high phosphorylation of ERalpha at Ser118 in the presence of tamoxifen; however, treatment with U0126 neither affected the level of Ser118 phosphorylation nor expression of the ERalpha target Bcl-2, suggesting that ERK contributes to cell growth independently of ERalpha in our cell model. | Tamoxifen | mitogen-activated protein kinase 1 | Homo sapiens |
| 3 | Together, these findings demonstrate that ERalpha is a major driver of growth in tamoxifen-resistant cells supported by HER/ERK growth signaling, implying that combined targeting of these pathways may have a clinical potential for overcoming tamoxifen resistance. | Tamoxifen | mitogen-activated protein kinase 1 | Homo sapiens |
| 4 | Together, these findings demonstrate that ERalpha is a major driver of growth in tamoxifen-resistant cells supported by HER/ERK growth signaling, implying that combined targeting of these pathways may have a clinical potential for overcoming tamoxifen resistance. | Tamoxifen | mitogen-activated protein kinase 1 | Homo sapiens |