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35107368 | p17-Modulated Hsp90/Cdc37 Complex Governs Oncolytic Avian Reovirus Replication by Chaperoning p17, Which Promotes Viral Protein Synthesis and Accumulation of Viral Proteins σC and σA in Viral Factories. | 2022 Mar 23 |
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35238566 | Discovery of Novel Celastrol-Imidazole Derivatives with Anticancer Activity In Vitro and In Vivo. | 2022 Mar 24 |
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33845380 | Discovery of novel celastrol-triazole derivatives with Hsp90-Cdc37 disruption to induce tumor cell apoptosis. | 2021 Jun |
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34170694 | Synthesis and Biological Evaluation of Celastrol Derivatives with Improved Cytotoxic Selectivity and Antitumor Activities. | 2021 Jul 23 |
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32222543 | Proteostasis regulators as potential rescuers of PMM2 activity. | 2020 Jul 1 |
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31051401 | Design, synthesis and antitumor evaluation of novel celastrol derivatives. | 2019 Jul 15 |
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31725288 | Discovery of Novel Celastrol Derivatives as Hsp90-Cdc37 Interaction Disruptors with Antitumor Activity. | 2019 Dec 12 |
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29274099 | Effects of celastrol on Tau hyperphosphorylation and expression of HSF-1 and HSP70 in SH-SY5Y neuroblastoma cells induced by amyloid-β peptides. | 2018 May |
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29534015 | Targeting Hodgkin and Reed-Sternberg Cells with an Inhibitor of Heat-Shock Protein 90: Molecular Pathways of Response and Potential Mechanisms of Resistance. | 2018 Mar 13 |
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30316059 | Discovery of novel NO-releasing celastrol derivatives with Hsp90 inhibition and cytotoxic activities. | 2018 Dec 5 |
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30588010 | Celastrol induces ubiquitin-dependent degradation of mTOR in breast cancer cells. | 2018 |
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27235383 | Exosomal formulation enhances therapeutic response of celastrol against lung cancer. | 2016 Aug |
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27398312 | Mutations Y493G and K546D in human HSP90 disrupt binding of celastrol and reduce interaction with Cdc37. | 2016 Jul |
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27647369 | Optimization and biological evaluation of celastrol derivatives as Hsp90-Cdc37 interaction disruptors with improved druglike properties. | 2016 Nov 1 |
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25989799 | Withaferin A Regulates LRRK2 Levels by Interfering with the Hsp90- Cdc37 Chaperone Complex. | 2015 |
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26227505 | Hsp90 Activity Modulation by Plant Secondary Metabolites. | 2015 Sep |
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26391399 | Disruption of Heat Shock Protein 90 (Hsp90)-Protein Kinase Cδ (PKCδ) Interaction by (-)-Maackiain Suppresses Histamine H1 Receptor Gene Transcription in HeLa Cells. | 2015 Nov 6 |
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26447544 | Synergistic anticancer effects of triptolide and celastrol, two main compounds from thunder god vine. | 2015 Oct 20 |
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24265268 | IP-FCM platform detects the existence and regulator-caused dissociation of components in naturally assembled HSP90 complex. | 2014 Apr |
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24351928 | Celastrol increases glucocerebrosidase activity in Gaucher disease by modulating molecular chaperones. | 2014 Jan 7 |
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24713615 | Alteration of the proteostasis network of plant cells promotes the post-endoplasmic reticulum trafficking of recombinant mutant (L444P) human β-glucocerebrosidase. | 2014 |
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24810052 | Celastrol targets proteostasis and acts synergistically with a heat-shock protein 90 inhibitor to kill human glioblastoma cells. | 2014 May 8 |
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24954307 | The effect of celastrol, a triterpene with antitumorigenic activity, on conformational and functional aspects of the human 90kDa heat shock protein Hsp90α, a chaperone implicated in the stabilization of the tumor phenotype. | 2014 Oct |
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24056254 | Expression and purification of recombinant NRL-Hsp90α and Cdc37-CRL proteins for in vitro Hsp90/Cdc37 inhibitors screening. | 2013 Nov |
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21866552 | Paraptosis accompanied by autophagy and apoptosis was induced by celastrol, a natural compound with influence on proteasome, ER stress and Hsp90. | 2012 May |
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21088503 | Anticancer activity of Celastrol in combination with ErbB2-targeted therapeutics for treatment of ErbB2-overexpressing breast cancers. | 2011 Jan 15 |
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21129982 | A systematic protocol for the characterization of Hsp90 modulators. | 2011 Jan 1 |
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21249311 | Enhancement of radiation sensitivity in lung cancer cells by celastrol is mediated by inhibition of Hsp90. | 2011 Mar |
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21569548 | Celastrol targets mitochondrial respiratory chain complex I to induce reactive oxygen species-dependent cytotoxicity in tumor cells. | 2011 May 14 |
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22087583 | Remarkable stereospecific conjugate additions to the Hsp90 inhibitor celastrol. | 2011 Dec 14 |
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19996313 | Celastrol inhibits Hsp90 chaperoning of steroid receptors by inducing fibrillization of the Co-chaperone p23. | 2010 Feb 5 |
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20007406 | Pharmacogenomic approach reveals a role for the x(c)- cystine/glutamate antiporter in growth and celastrol resistance of glioma cell lines. | 2010 Mar |
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20226165 | Celastrol: Molecular targets of Thunder God Vine. | 2010 Apr 9 |
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20398364 | HSP90 inhibitor, celastrol, arrests human monocytic leukemia cell U937 at G0/G1 in thiol-containing agents reversible way. | 2010 Apr 16 |
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20480272 | Celastrol regulates multiple nuclear transcription factors belonging to HSP90's clients in a dose- and cell type-dependent way. | 2010 Nov |
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19585625 | Molecular mechanism of inhibition of the human protein complex Hsp90-Cdc37, a kinome chaperone-cochaperone, by triterpene celastrol. | 2009 |
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19858214 | Characterization of celastrol to inhibit hsp90 and cdc37 interaction. | 2009 Dec 18 |
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19138996 | Heat shock protein 90 inhibitors suppress aryl hydrocarbon receptor-mediated activation of CYP1A1 and CYP1B1 transcription and DNA adduct formation. | 2008 Nov |
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17010675 | Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators. | 2006 Oct |
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