Title : Alteration of the proteostasis network of plant cells promotes the post-endoplasmic reticulum trafficking of recombinant mutant (L444P) human β-glucocerebrosidase.

Pub. Date : 2014

PMID : 24713615






2 Functional Relationships(s)
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1 An exception was the marked response to celastrol which reduced the steady-state levels of cytoplasmic HSP90 transcripts and protein. celastrol heat shock protein 90 alpha family class A member 1 Homo sapiens
2 As Hsp90 participates in the targeting of misfolded proteins to the proteasome pathway, its down-modulation in response to celastrol may partly account for the mechanism of improved homeostasis of L444P GCase mediated by this triterpene. celastrol heat shock protein 90 alpha family class A member 1 Homo sapiens