Pub. Date : 2010 Feb 5
PMID : 19996313
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Celastrol inhibits Hsp90 chaperoning of steroid receptors by inducing fibrillization of the Co-chaperone p23. | celastrol | heat shock protein 90 alpha family class A member 1 | Homo sapiens |
| 2 | Here, we show that the small molecule celastrol inhibits the Hsp90 chaperoning machinery by inactivating the co-chaperone p23, resulting in a more selective destabilization of steroid receptors compared with kinase clients. | celastrol | heat shock protein 90 alpha family class A member 1 | Homo sapiens |