PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31725288-1 2019 To develop novel and efficient heat shock protein 90-cell division cycle 37 (Hsp90-Cdc37) interaction disruptors, several lipophilic fragments were introduced into celastrol (CEL) to synthesize 48 new CEL derivatives. celastrol 175-178 heat shock protein 90 alpha family class A member 1 Homo sapiens 77-82 34170694-2 2021 Celastrol, a natural friedelane triterpenoid, can disrupt the Hsp90-Cdc37 interaction to provide antitumor effects. celastrol 0-9 heat shock protein 90 alpha family class A member 1 Homo sapiens 62-67 34170694-3 2021 In this study, 31 new celastrol derivatives, 2a-2d, 3a-3g, and 4a-4t, were designed and synthesized, and their Hsp90-Cdc37 disruption activities and antiproliferative activities against cancer cells were evaluated. celastrol 22-31 heat shock protein 90 alpha family class A member 1 Homo sapiens 111-116 31725288-0 2019 Discovery of novel celastrol derivatives as Hsp90-Cdc37 interaction disruptors with antitumour activity. celastrol 19-28 heat shock protein 90 alpha family class A member 1 Homo sapiens 44-49 31725288-1 2019 To develop novel and efficient heat shock protein 90-cell division cycle 37 (Hsp90-Cdc37) interaction disruptors, several lipophilic fragments were introduced into celastrol (CEL) to synthesize 48 new CEL derivatives. celastrol 164-173 heat shock protein 90 alpha family class A member 1 Homo sapiens 77-82 35238566-1 2022 To discover celastrol (CEL) derivatives with enhanced Hsp90-Cdc37 inhibition, C-20-COOH was introduced with various substituted imidazoles, which might affect the Michael addition of CEL by nucleophilic attack. celastrol 12-21 heat shock protein 90 alpha family class A member 1 Homo sapiens 54-59 35238566-1 2022 To discover celastrol (CEL) derivatives with enhanced Hsp90-Cdc37 inhibition, C-20-COOH was introduced with various substituted imidazoles, which might affect the Michael addition of CEL by nucleophilic attack. celastrol 23-26 heat shock protein 90 alpha family class A member 1 Homo sapiens 54-59 35238566-1 2022 To discover celastrol (CEL) derivatives with enhanced Hsp90-Cdc37 inhibition, C-20-COOH was introduced with various substituted imidazoles, which might affect the Michael addition of CEL by nucleophilic attack. celastrol 183-186 heat shock protein 90 alpha family class A member 1 Homo sapiens 54-59 35107368-3 2022 Iinhibition of the Hsp90/Cdc37 complex by inhibitors (17-AAG and celastrol) or shRNAs significantly reduced expression levels of viral proteins and virus yield, suggesting that the Hsp90/Cdc37 chaperone complex functions in virus replication. celastrol 65-74 heat shock protein 90 alpha family class A member 1 Homo sapiens 19-24 33845380-0 2021 Discovery of novel celastrol-triazole derivatives with Hsp90-Cdc37 disruption to induce tumor cell apoptosis. celastrol 19-28 heat shock protein 90 alpha family class A member 1 Homo sapiens 55-60 32222543-7 2020 The increase in enzymatic activity with celastrol correlated with an increase in the transcriptional and proteome levels of the heat shock proteins Hsp90 and Hsp70. celastrol 40-49 heat shock protein 90 alpha family class A member 1 Homo sapiens 148-153 32222543-8 2020 The use of specific Hsp70 or Hsp90 inhibitors showed the positive effect of celastrol on PMM2 stability and activity to occur through Hsp90-driven modulation of the proteostasis network. celastrol 76-85 heat shock protein 90 alpha family class A member 1 Homo sapiens 29-34 32222543-8 2020 The use of specific Hsp70 or Hsp90 inhibitors showed the positive effect of celastrol on PMM2 stability and activity to occur through Hsp90-driven modulation of the proteostasis network. celastrol 76-85 heat shock protein 90 alpha family class A member 1 Homo sapiens 134-139 31725288-1 2019 To develop novel and efficient heat shock protein 90-cell division cycle 37 (Hsp90-Cdc37) interaction disruptors, several lipophilic fragments were introduced into celastrol (CEL) to synthesize 48 new CEL derivatives. celastrol 201-204 heat shock protein 90 alpha family class A member 1 Homo sapiens 77-82 31725288-3 2019 The capability to disrupt the Hsp90-Cdc37 interaction was stronger than that of CEL. celastrol 80-83 heat shock protein 90 alpha family class A member 1 Homo sapiens 30-35 27398312-0 2016 Mutations Y493G and K546D in human HSP90 disrupt binding of celastrol and reduce interaction with Cdc37. celastrol 60-69 heat shock protein 90 alpha family class A member 1 Homo sapiens 35-40 31051401-3 2019 The mechanism of pharmacological research indicated that 29 possessed the ability to disrupt Hsp90-Cdc37 complex which was stronger than celastrol. celastrol 137-146 heat shock protein 90 alpha family class A member 1 Homo sapiens 93-98 30588010-10 2018 Mechanistically, we found that mTOR is a client of Hsp90-Cdc37 chaperone complex, and celastrol disrupts mTOR interaction with chaperone Hsp90 while promoting mTOR association with cochaperone Cdc37. celastrol 86-95 heat shock protein 90 alpha family class A member 1 Homo sapiens 51-56 30588010-10 2018 Mechanistically, we found that mTOR is a client of Hsp90-Cdc37 chaperone complex, and celastrol disrupts mTOR interaction with chaperone Hsp90 while promoting mTOR association with cochaperone Cdc37. celastrol 86-95 heat shock protein 90 alpha family class A member 1 Homo sapiens 137-142 30316059-0 2018 Discovery of novel NO-releasing celastrol derivatives with Hsp90 inhibition and cytotoxic activities. celastrol 32-41 heat shock protein 90 alpha family class A member 1 Homo sapiens 59-64 29534015-2 2018 Here, we report the antitumor effect of celastrol, an anti-inflammatory compound and a recognized HSP90 inhibitor, in Hodgkin and Reed-Sternberg cell lines. celastrol 40-49 heat shock protein 90 alpha family class A member 1 Homo sapiens 98-103 29274099-5 2018 Meanwhile, both celastrol treatment and knockdown of HSP70 or HSF-1 in SH-SY5Y cells significantly inhibited the Tau hyperphosphorylation and HSP90 expression induced by Abeta1-42 . celastrol 16-25 heat shock protein 90 alpha family class A member 1 Homo sapiens 142-147 27647369-0 2016 Optimization and biological evaluation of celastrol derivatives as Hsp90-Cdc37 interaction disruptors with improved druglike properties. celastrol 42-51 heat shock protein 90 alpha family class A member 1 Homo sapiens 67-72 27647369-5 2016 Celastrol, as a natural product, can disrupt the Hsp90-Cdc37 interaction and induce degradation of kinase clients. celastrol 0-9 heat shock protein 90 alpha family class A member 1 Homo sapiens 49-54 27647369-6 2016 The study conducted here attempted to elucidate the structure-activity relationship of celastrol derivatives as Hsp90-Cdc37 disruptors and to improve the druglike properties. celastrol 87-96 heat shock protein 90 alpha family class A member 1 Homo sapiens 112-117 27235383-1 2016 Celastrol (CEL), a plant-derived triterpenoid, is a known inhibitor of Hsp90 and NF-kappaB activation pathways and has recently been suggested to be of therapeutic importance in various cancers. celastrol 0-9 heat shock protein 90 alpha family class A member 1 Homo sapiens 71-76 27235383-1 2016 Celastrol (CEL), a plant-derived triterpenoid, is a known inhibitor of Hsp90 and NF-kappaB activation pathways and has recently been suggested to be of therapeutic importance in various cancers. celastrol 11-14 heat shock protein 90 alpha family class A member 1 Homo sapiens 71-76 27398312-1 2016 Celastrol, a natural compound derived from the Chinese herb Tripterygium wilfordii Hook F, has been proven to inhibit heat shock protein 90 (HSP90) activity and has attracted much attention because of its promising effects in cancer treatment and in ameliorating degenerative neuron diseases. celastrol 0-9 heat shock protein 90 alpha family class A member 1 Homo sapiens 141-146 27398312-2 2016 However, the HSP90 structure involved in celastrol interaction is not known. celastrol 41-50 heat shock protein 90 alpha family class A member 1 Homo sapiens 13-18 27398312-3 2016 Here, we report a novel celastrol-binding pocket in the HSP90 dimer, predicted by molecular docking. celastrol 24-33 heat shock protein 90 alpha family class A member 1 Homo sapiens 56-61 27398312-4 2016 Mutation of the two key binding pocket amino acids (Lys546 and Tyr493) disrupted the binding of celastrol to HSP90 dimers, as detected by isothermal titration calorimetry (ITC). celastrol 96-105 heat shock protein 90 alpha family class A member 1 Homo sapiens 109-114 27398312-5 2016 Interestingly, such mutations also reduced binding between HSP90 and the cochaperone Cdc37, thus providing a new explanation for reported findings that celastrol shows more obvious effects in disrupting binding between HSP90 and Cdc37 than between HSP90 and other cochaperones. celastrol 152-161 heat shock protein 90 alpha family class A member 1 Homo sapiens 59-64 27398312-5 2016 Interestingly, such mutations also reduced binding between HSP90 and the cochaperone Cdc37, thus providing a new explanation for reported findings that celastrol shows more obvious effects in disrupting binding between HSP90 and Cdc37 than between HSP90 and other cochaperones. celastrol 152-161 heat shock protein 90 alpha family class A member 1 Homo sapiens 219-224 27398312-5 2016 Interestingly, such mutations also reduced binding between HSP90 and the cochaperone Cdc37, thus providing a new explanation for reported findings that celastrol shows more obvious effects in disrupting binding between HSP90 and Cdc37 than between HSP90 and other cochaperones. celastrol 152-161 heat shock protein 90 alpha family class A member 1 Homo sapiens 219-224 27398312-6 2016 In short, our work discloses a novel binding pocket in HSP90 dimer for celastrol and provides an explanation as to why celastrol has a strong effect on HSP90 and Cdc37 binding. celastrol 71-80 heat shock protein 90 alpha family class A member 1 Homo sapiens 55-60 27398312-6 2016 In short, our work discloses a novel binding pocket in HSP90 dimer for celastrol and provides an explanation as to why celastrol has a strong effect on HSP90 and Cdc37 binding. celastrol 71-80 heat shock protein 90 alpha family class A member 1 Homo sapiens 152-157 27398312-6 2016 In short, our work discloses a novel binding pocket in HSP90 dimer for celastrol and provides an explanation as to why celastrol has a strong effect on HSP90 and Cdc37 binding. celastrol 119-128 heat shock protein 90 alpha family class A member 1 Homo sapiens 55-60 27398312-6 2016 In short, our work discloses a novel binding pocket in HSP90 dimer for celastrol and provides an explanation as to why celastrol has a strong effect on HSP90 and Cdc37 binding. celastrol 119-128 heat shock protein 90 alpha family class A member 1 Homo sapiens 152-157 26447544-5 2015 Treatment with celastrol alone led to the decreased expressions of HSP90 client proteins including survivin, AKT, EGFR, which was enhanced by the addition of triptolide. celastrol 15-24 heat shock protein 90 alpha family class A member 1 Homo sapiens 67-72 26391399-7 2015 Additional Hsp90 inhibitors, including 17-(allylamino)-17-demethoxygeldanamycin, celastrol, and novobiocin also suppressed PMA-induced H1R gene up-regulation. celastrol 81-90 heat shock protein 90 alpha family class A member 1 Homo sapiens 11-16 24954307-0 2014 The effect of celastrol, a triterpene with antitumorigenic activity, on conformational and functional aspects of the human 90kDa heat shock protein Hsp90alpha, a chaperone implicated in the stabilization of the tumor phenotype. celastrol 14-23 heat shock protein 90 alpha family class A member 1 Homo sapiens 148-158 26227505-6 2015 Recently, several plant-derived small molecules have been discovered exhibiting inhibitory activity towards Hsp90, such as epigallocatechin gallate, gedunin, lentiginosine, celastrol, and deguelin. celastrol 173-182 heat shock protein 90 alpha family class A member 1 Homo sapiens 108-113 25989799-8 2015 Additionally, treatment with celastrol, which is also an inhibitor of the Hsp90-Cdc37 complex, decreased LRRK2 levels. celastrol 29-38 heat shock protein 90 alpha family class A member 1 Homo sapiens 74-79 24954307-3 2014 RESULTS: In this work, we investigated the effect of celastrol on the conformational and functional aspects of Hsp90alpha. celastrol 53-62 heat shock protein 90 alpha family class A member 1 Homo sapiens 111-121 24954307-4 2014 Interestingly, celastrol appeared to target Hsp90alpha directly as the compound induced the oligomerization of the chaperone via the C-terminal domain as demonstrated by experiments using a deletion mutant. celastrol 15-24 heat shock protein 90 alpha family class A member 1 Homo sapiens 44-54 24954307-5 2014 The nature of the oligomers was investigated by biophysical tools demonstrating that a two-fold excess of celastrol induced the formation of a decameric Hsp90alpha bound throughout the C-terminal domain. celastrol 106-115 heat shock protein 90 alpha family class A member 1 Homo sapiens 153-163 24954307-8 2014 CONCLUSION: Celastrol interferes with specific biological functions of Hsp90alpha. celastrol 12-21 heat shock protein 90 alpha family class A member 1 Homo sapiens 71-81 24954307-9 2014 Our results suggest a model in which celastrol binds directly to the C-terminal domain of Hsp90alpha causing oligomerization. celastrol 37-46 heat shock protein 90 alpha family class A member 1 Homo sapiens 90-100 24954307-11 2014 Therefore celastrol may act primarily by inducing specific oligomerization that affects some, but not all, of the functions of Hsp90alpha. celastrol 10-19 heat shock protein 90 alpha family class A member 1 Homo sapiens 127-137 24954307-12 2014 GENERAL SIGNIFICANCE: To the best of our knowledge, this study is the first work to use multiple probes to investigate the effect that celastrol has on the stability and oligomerization of Hsp90alpha and on the binding of this chaperone to Tom70. celastrol 135-144 heat shock protein 90 alpha family class A member 1 Homo sapiens 189-199 24954307-13 2014 This work provides a novel mechanism by which celastrol binds Hsp90alpha. celastrol 46-55 heat shock protein 90 alpha family class A member 1 Homo sapiens 62-72 24351928-4 2014 Celastrol interfered with the establishment of the heat-shock protein 90/Hsp90 cochaperone Cdc37/Hsp90-Hsp70-organizing protein chaperone complex with mutant GCase and reduced heat-shock protein 90-associated protein degradation. celastrol 0-9 heat shock protein 90 alpha family class A member 1 Homo sapiens 73-78 24265268-5 2014 In a cell-free environment, IP-FCM could detect the direct effects of ATP and/or HSP90 inhibitors (17-N-allylamino-17-demethoxygeldanamycin or celastrol) in causing component dissociation and the time- and dose-effects of inhibitor-caused dissociation. celastrol 143-152 heat shock protein 90 alpha family class A member 1 Homo sapiens 81-86 24810052-5 2014 Our studies indicate that celastrol promotes proteotoxic stress, supported by two feedback mechanisms: (i) impairment of protein quality control as revealed by accumulation of polyubiquitinated aggregates and the canonical autophagy substrate, p62, and (ii) the induction of heat-shock proteins, HSP72 and HSP90. celastrol 26-35 heat shock protein 90 alpha family class A member 1 Homo sapiens 306-311 24810052-9 2014 This study further emphasizes that targeting proteotoxic stress responses by inhibiting HSP90 with 17-N-Allylamino-17-demethoxygeldanamycin sensitizes human glioblastoma to celastrol treatment, thereby serving as a novel synergism to overcome drug resistance. celastrol 173-182 heat shock protein 90 alpha family class A member 1 Homo sapiens 88-93 24713615-7 2014 An exception was the marked response to celastrol which reduced the steady-state levels of cytoplasmic HSP90 transcripts and protein. celastrol 40-49 heat shock protein 90 alpha family class A member 1 Homo sapiens 103-108 24713615-8 2014 As Hsp90 participates in the targeting of misfolded proteins to the proteasome pathway, its down-modulation in response to celastrol may partly account for the mechanism of improved homeostasis of L444P GCase mediated by this triterpene. celastrol 123-132 heat shock protein 90 alpha family class A member 1 Homo sapiens 3-8 24351928-4 2014 Celastrol interfered with the establishment of the heat-shock protein 90/Hsp90 cochaperone Cdc37/Hsp90-Hsp70-organizing protein chaperone complex with mutant GCase and reduced heat-shock protein 90-associated protein degradation. celastrol 0-9 heat shock protein 90 alpha family class A member 1 Homo sapiens 97-102 21866552-0 2012 Paraptosis accompanied by autophagy and apoptosis was induced by celastrol, a natural compound with influence on proteasome, ER stress and Hsp90. celastrol 65-74 heat shock protein 90 alpha family class A member 1 Homo sapiens 139-144 24056254-10 2013 Very interestingly, Sulforaphane, Withaferin A, Celastrol and EGCG all decreased the complemented NRL-Hsp90alpha/Cdc37-CRL activities in the concentration-dependent manner. celastrol 48-57 heat shock protein 90 alpha family class A member 1 Homo sapiens 102-112 21866552-10 2012 The potency of celastrol to induce paraptosis, apoptosis and autophagy at the same dose might be related to its capability to affect a variety of pathways including proteasome, ER stress and Hsp90. celastrol 15-24 heat shock protein 90 alpha family class A member 1 Homo sapiens 191-196 22087583-0 2011 Remarkable stereospecific conjugate additions to the Hsp90 inhibitor celastrol. celastrol 69-78 heat shock protein 90 alpha family class A member 1 Homo sapiens 53-58 22087583-1 2011 Celastrol, an important natural product and Hsp90 inhibitor with a wide range of biological and medical activities and broad use as a biological probe, acts by an as yet undetermined mode of action. celastrol 0-9 heat shock protein 90 alpha family class A member 1 Homo sapiens 44-49 21569548-12 2011 Celastrol downregulated HSP90 client proteins but did not disrupt the interaction between HSP90 and cdc37. celastrol 0-9 heat shock protein 90 alpha family class A member 1 Homo sapiens 24-29 21569548-13 2011 NAC completely inhibited celastrol-induced decrease of HSP90 client proteins, catalase and thioredoxin. celastrol 25-34 heat shock protein 90 alpha family class A member 1 Homo sapiens 55-60 21569548-18 2011 Celastrol induced the downregulation of HSP90 client proteins through ROS accumulation and facilitated ROS accumulation by inhibiting MRC complex I activity. celastrol 0-9 heat shock protein 90 alpha family class A member 1 Homo sapiens 40-45 20480272-0 2010 Celastrol regulates multiple nuclear transcription factors belonging to HSP90"s clients in a dose- and cell type-dependent way. celastrol 0-9 heat shock protein 90 alpha family class A member 1 Homo sapiens 72-77 21088503-3 2011 The triterpene natural product Celastrol inhibits HSP90 and several pathways relevant to ErbB2-dependent oncogenesis including the NFkappaB pathway and the proteasome, and has shown promising activity in other cancer models. celastrol 31-40 heat shock protein 90 alpha family class A member 1 Homo sapiens 50-55 21088503-7 2011 Mechanistically, Celastrol not only induced the expected ubiquitinylation and degradation of ErbB2 and other HSP90 client proteins, but it also increased the levels of reactive oxygen species (ROS). celastrol 17-26 heat shock protein 90 alpha family class A member 1 Homo sapiens 109-114 21129982-1 2011 Several Hsp90 modulators have been identified including the N-terminal ligand geldanamycin (GDA), the C-terminal ligand novobiocin (NB), and the co-chaperone disruptor celastrol. celastrol 168-177 heat shock protein 90 alpha family class A member 1 Homo sapiens 8-13 21249311-0 2011 Enhancement of radiation sensitivity in lung cancer cells by celastrol is mediated by inhibition of Hsp90. celastrol 61-70 heat shock protein 90 alpha family class A member 1 Homo sapiens 100-105 21249311-4 2011 Celastrol inhibited the ATP-binding activity of Hsp90. celastrol 0-9 heat shock protein 90 alpha family class A member 1 Homo sapiens 48-53 21249311-5 2011 Furthermore, celastrol treatment dissociated an Hsp90 client protein, EGFR, and this in turn resulted in degradation of the client protein. celastrol 13-22 heat shock protein 90 alpha family class A member 1 Homo sapiens 48-53 21249311-8 2011 Celastrol may be considered an effective radiosensitizer acting as an inhibitor of Hsp90 and a p53 activator. celastrol 0-9 heat shock protein 90 alpha family class A member 1 Homo sapiens 83-88 20480272-1 2010 Celastrol, a novel HSP90 inhibitor, has recently attracted much attention due to its potential in multiple applications, such as anti-inflammation use, degenerative neuron disease relief, and tumor management. celastrol 0-9 heat shock protein 90 alpha family class A member 1 Homo sapiens 19-24 20480272-2 2010 At present, the studies in celastrol"s effects on HSP90"s clients have focused on the kinase sub-population, while another key sub-population, nuclear transcription factors (TFs), is not being well-explored. celastrol 27-36 heat shock protein 90 alpha family class A member 1 Homo sapiens 50-55 20480272-3 2010 In this study, we observe the effects of celastrol on 18 TFs (belonging to HSP90 clients) in three human cell lines: MCF-7 (breast cancer), HepG2 (hepatoma), and THP-1 (monocytic leukemia). celastrol 41-50 heat shock protein 90 alpha family class A member 1 Homo sapiens 75-80 20480272-6 2010 Celastrol"s capability to affect multiple TFs was consistent with its altering HSP90/TFs interactions and disrupting HSP90/Hop interaction, in addition to the reported damaging HSP90/Cdc37 interaction. celastrol 0-9 heat shock protein 90 alpha family class A member 1 Homo sapiens 79-84 20480272-6 2010 Celastrol"s capability to affect multiple TFs was consistent with its altering HSP90/TFs interactions and disrupting HSP90/Hop interaction, in addition to the reported damaging HSP90/Cdc37 interaction. celastrol 0-9 heat shock protein 90 alpha family class A member 1 Homo sapiens 117-122 20480272-6 2010 Celastrol"s capability to affect multiple TFs was consistent with its altering HSP90/TFs interactions and disrupting HSP90/Hop interaction, in addition to the reported damaging HSP90/Cdc37 interaction. celastrol 0-9 heat shock protein 90 alpha family class A member 1 Homo sapiens 117-122 20480272-7 2010 This work confirms, for the first time, that celastrol has broad effects on TFs belonging to HSP90"s clients, casts new light on understanding these reported actions, and suggests new possible applications for celastrol, such as diabetes management. celastrol 45-54 heat shock protein 90 alpha family class A member 1 Homo sapiens 93-98 20007406-2 2010 Celastrol, isolated from a Chinese medicinal herb, is a novel heat shock protein 90 (Hsp90) inhibitor with potent anticancer activity against glioma in vitro and in vivo. celastrol 0-9 heat shock protein 90 alpha family class A member 1 Homo sapiens 62-83 20398364-0 2010 HSP90 inhibitor, celastrol, arrests human monocytic leukemia cell U937 at G0/G1 in thiol-containing agents reversible way. celastrol 17-26 heat shock protein 90 alpha family class A member 1 Homo sapiens 0-5 20398364-2 2010 Recently, celastrol is identified both as a novel inhibitor of HSP90 and as a potential anti-tumor agent. celastrol 10-19 heat shock protein 90 alpha family class A member 1 Homo sapiens 63-68 20398364-8 2010 CONCLUSIONS: Our results disclose a novel action of celastrol-- causing cell cycle arrest at G0/G1 phase based upon thiol-related HSP90 inhibition. celastrol 52-61 heat shock protein 90 alpha family class A member 1 Homo sapiens 130-135 20226165-4 2010 Celastrol (i) inhibits directly the IKKalpha and beta kinases, (ii) inactivates the Cdc37 and p23 proteins which are co-chaperones of HSP90, (iii) inhibits the function of proteasomes, and (iv) activates the HSF1 and subsequently triggers the heat shock response. celastrol 0-9 heat shock protein 90 alpha family class A member 1 Homo sapiens 134-139 20007406-2 2010 Celastrol, isolated from a Chinese medicinal herb, is a novel heat shock protein 90 (Hsp90) inhibitor with potent anticancer activity against glioma in vitro and in vivo. celastrol 0-9 heat shock protein 90 alpha family class A member 1 Homo sapiens 85-90 20007406-8 2010 Combined treatment of glioma cells with sulfasalazine and celastrol led to chemosensitization, as suggested by increased celastrol-induced cell cycle arrest, apoptosis, and down-regulation of the Hsp90 client protein, epidermal growth factor receptor. celastrol 58-67 heat shock protein 90 alpha family class A member 1 Homo sapiens 196-201 20007406-8 2010 Combined treatment of glioma cells with sulfasalazine and celastrol led to chemosensitization, as suggested by increased celastrol-induced cell cycle arrest, apoptosis, and down-regulation of the Hsp90 client protein, epidermal growth factor receptor. celastrol 121-130 heat shock protein 90 alpha family class A member 1 Homo sapiens 196-201 19996313-0 2010 Celastrol inhibits Hsp90 chaperoning of steroid receptors by inducing fibrillization of the Co-chaperone p23. celastrol 0-9 heat shock protein 90 alpha family class A member 1 Homo sapiens 19-24 19996313-3 2010 Here, we show that the small molecule celastrol inhibits the Hsp90 chaperoning machinery by inactivating the co-chaperone p23, resulting in a more selective destabilization of steroid receptors compared with kinase clients. celastrol 38-47 heat shock protein 90 alpha family class A member 1 Homo sapiens 61-66 19585625-0 2009 Molecular mechanism of inhibition of the human protein complex Hsp90-Cdc37, a kinome chaperone-cochaperone, by triterpene celastrol. celastrol 122-131 heat shock protein 90 alpha family class A member 1 Homo sapiens 63-68 19858214-0 2009 Characterization of celastrol to inhibit hsp90 and cdc37 interaction. celastrol 20-29 heat shock protein 90 alpha family class A member 1 Homo sapiens 41-46 19858214-6 2009 Celastrol disrupts Hsp90-Cdc37 complex formation, whereas the classical Hsp90 inhibitors (e.g. geldanamycin) have no effect. celastrol 0-9 heat shock protein 90 alpha family class A member 1 Homo sapiens 19-24 19858214-7 2009 Celastrol inhibits Hsp90 ATPase activity without blocking ATP binding. celastrol 0-9 heat shock protein 90 alpha family class A member 1 Homo sapiens 19-24 19858214-8 2009 Proteolytic fingerprinting indicates celastrol binds to Hsp90 C-terminal domain to protect it from trypsin digestion. celastrol 37-46 heat shock protein 90 alpha family class A member 1 Homo sapiens 56-61 19858214-9 2009 These data suggest that celastrol may represent a new class of Hsp90 inhibitor by modifying Hsp90 C terminus to allosterically regulate its chaperone activity and disrupt Hsp90-Cdc37 complex. celastrol 24-33 heat shock protein 90 alpha family class A member 1 Homo sapiens 63-68 19858214-9 2009 These data suggest that celastrol may represent a new class of Hsp90 inhibitor by modifying Hsp90 C terminus to allosterically regulate its chaperone activity and disrupt Hsp90-Cdc37 complex. celastrol 24-33 heat shock protein 90 alpha family class A member 1 Homo sapiens 92-97 19858214-9 2009 These data suggest that celastrol may represent a new class of Hsp90 inhibitor by modifying Hsp90 C terminus to allosterically regulate its chaperone activity and disrupt Hsp90-Cdc37 complex. celastrol 24-33 heat shock protein 90 alpha family class A member 1 Homo sapiens 92-97 19138996-5 2008 Inhibitors of HSP90 [17-allylamino-17-demethoxygeldanamycin (17-AAG); celastrol] suppressed these inductive effects of PAHs. celastrol 70-79 heat shock protein 90 alpha family class A member 1 Homo sapiens 14-19 19138996-6 2008 Treatment with 17-AAG and celastrol also caused a rapid and marked decrease in amounts of AhR protein without modulating levels of HSP90. celastrol 26-35 heat shock protein 90 alpha family class A member 1 Homo sapiens 131-136 19138996-8 2008 The reduction in B(a)P-induced DNA adducts was due, at least in part, to reduced metabolic activation of B(a)P. Collectively, these results suggest that 17-AAG and celastrol, inhibitors of HSP90, suppress the activation of AhR-dependent gene expression, leading, in turn, to reduced formation of B(a)P-induced DNA adducts. celastrol 164-173 heat shock protein 90 alpha family class A member 1 Homo sapiens 189-194 17010675-5 2006 Validating this prediction, we demonstrate that celastrol and gedunin inhibit HSP90 activity and HSP90 clients, including AR. celastrol 48-57 heat shock protein 90 alpha family class A member 1 Homo sapiens 78-83 17010675-5 2006 Validating this prediction, we demonstrate that celastrol and gedunin inhibit HSP90 activity and HSP90 clients, including AR. celastrol 48-57 heat shock protein 90 alpha family class A member 1 Homo sapiens 97-102