Title : Celastrol induces ubiquitin-dependent degradation of mTOR in breast cancer cells.

Pub. Date : 2018

PMID : 30588010






2 Functional Relationships(s)
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1 Mechanistically, we found that mTOR is a client of Hsp90-Cdc37 chaperone complex, and celastrol disrupts mTOR interaction with chaperone Hsp90 while promoting mTOR association with cochaperone Cdc37. celastrol heat shock protein 90 alpha family class A member 1 Homo sapiens
2 Mechanistically, we found that mTOR is a client of Hsp90-Cdc37 chaperone complex, and celastrol disrupts mTOR interaction with chaperone Hsp90 while promoting mTOR association with cochaperone Cdc37. celastrol heat shock protein 90 alpha family class A member 1 Homo sapiens