Pub. Date : 2008 Nov
PMID : 19138996
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Inhibitors of HSP90 [17-allylamino-17-demethoxygeldanamycin (17-AAG); celastrol] suppressed these inductive effects of PAHs. | celastrol | heat shock protein 90 alpha family class A member 1 | Homo sapiens |
| 2 | Treatment with 17-AAG and celastrol also caused a rapid and marked decrease in amounts of AhR protein without modulating levels of HSP90. | celastrol | heat shock protein 90 alpha family class A member 1 | Homo sapiens |
| 3 | The reduction in B(a)P-induced DNA adducts was due, at least in part, to reduced metabolic activation of B(a)P. Collectively, these results suggest that 17-AAG and celastrol, inhibitors of HSP90, suppress the activation of AhR-dependent gene expression, leading, in turn, to reduced formation of B(a)P-induced DNA adducts. | celastrol | heat shock protein 90 alpha family class A member 1 | Homo sapiens |