Title : Pharmacogenomic approach reveals a role for the x(c)- cystine/glutamate antiporter in growth and celastrol resistance of glioma cell lines.

Pub. Date : 2010 Mar

PMID : 20007406






4 Functional Relationships(s)
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Protein Name
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1 Celastrol, isolated from a Chinese medicinal herb, is a novel heat shock protein 90 (Hsp90) inhibitor with potent anticancer activity against glioma in vitro and in vivo. celastrol heat shock protein 90 alpha family class A member 1 Homo sapiens
2 Celastrol, isolated from a Chinese medicinal herb, is a novel heat shock protein 90 (Hsp90) inhibitor with potent anticancer activity against glioma in vitro and in vivo. celastrol heat shock protein 90 alpha family class A member 1 Homo sapiens
3 Combined treatment of glioma cells with sulfasalazine and celastrol led to chemosensitization, as suggested by increased celastrol-induced cell cycle arrest, apoptosis, and down-regulation of the Hsp90 client protein, epidermal growth factor receptor. celastrol heat shock protein 90 alpha family class A member 1 Homo sapiens
4 Combined treatment of glioma cells with sulfasalazine and celastrol led to chemosensitization, as suggested by increased celastrol-induced cell cycle arrest, apoptosis, and down-regulation of the Hsp90 client protein, epidermal growth factor receptor. celastrol heat shock protein 90 alpha family class A member 1 Homo sapiens