Tyrosine

MET proto-oncogene, receptor tyrosine kinase ; Homo sapiens







98 Article(s)
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1 33520371 Nuclear translocation of the receptor tyrosine kinase c-MET reduces the treatment efficacies of olaparib and gemcitabine in pancreatic ductal adenocarcinoma cells. 2021 2
2 34200450 Identification of Nucleolin as a Novel AEG-1-Interacting Protein in Breast Cancer via Interactome Profiling. 2021 Jun 7 1
3 31825565 Molecular Epitope Determination of Aptamer Complexes of the Multidomain Protein C-Met by Proteolytic Affinity-Mass Spectrometry. 2020 Feb 17 1
4 31881189 Dynasore potentiates c-Met inhibitors against hepatocellular carcinoma through destabilizing c-Met. 2020 Feb 15 1
5 31973231 Novel Peptide CM 7 Targeted c-Met with Antitumor Activity. 2020 Jan 21 3
6 32028611 New Preclinical Development of a c-Met Inhibitor and Its Combined Anti-Tumor Effect in c-Met-Amplified NSCLC. 2020 Feb 3 1
7 32070026 Licochalcone D Induces ROS-Dependent Apoptosis in Gefitinib-Sensitive or Resistant Lung Cancer Cells by Targeting EGFR and MET. 2020 Feb 13 1
8 30692572 Differential anti-tumour effects of MTH1 inhibitors in patient-derived 3D colorectal cancer cultures. 2019 Jan 28 1
9 30909596 New Phosphorylation Sites of Rad51 by c-Met Modulates Presynaptic Filament Stability. 2019 Mar 23 1
10 31584260 Design and Evaluation of PEGylated Liposomal Formulation of a Novel Multikinase Inhibitor for Enhanced Chemosensitivity and Inhibition of Metastatic Pancreatic Ductal Adenocarcinoma. 2019 Oct 16 2
11 31832192 Impact of MET alterations on targeted therapy with EGFR-tyrosine kinase inhibitors for EGFR-mutant lung cancer. 2019 1
12 31867280 Aberrant RON and MET Co-overexpression as Novel Prognostic Biomarkers of Shortened Patient Survival and Therapeutic Targets of Tyrosine Kinase Inhibitors in Pancreatic Cancer. 2019 1
13 30309648 Disproportionately high levels of HGF induce the degradation of the c-met receptor through the proteasomal degradation pathway. 2018 Nov 2 1
14 30466782 Prolonged MEK inhibition leads to acquired resistance and increased invasiveness in KRAS mutant gastric cancer. 2018 Dec 9 2
15 31949583 Immunostaining by dual tumor tissue paraffin blocks increases the sensitivity of c-Met detection in gastric cancer. 2018 1
16 28179995 Caspase-mediated proteolysis of the sorting nexin 2 disrupts retromer assembly and potentiates Met/hepatocyte growth factor receptor signaling. 2017 1
17 27773821 Tyrosine phosphorylation of RalGDS by c-Met receptor blocks its interaction with Ras. 2016 Nov 18 2
18 24362531 Effective inhibition of c-MET-mediated signaling, growth and migration of ovarian cancer cells is influenced by the ovarian tissue microenvironment. 2015 Jan 8 1
19 24634221 Role of c-Met/phosphatidylinositol 3-kinase (PI3k)/Akt signaling in hepatocyte growth factor (HGF)-mediated lamellipodia formation, reactive oxygen species (ROS) generation, and motility of lung endothelial cells. 2014 May 9 4
20 22996389 Dissociation of c-Met phosphotyrosine sites in human cells in response to mouse hepatocyte growth factor but not human hepatocyte growth factor: the possible roles of different amino acids in different species. 2013 Jun 2
21 23288161 Rhodocetin-αβ-induced neuropilin-1-cMet association triggers restructuring of matrix contacts in endothelial cells. 2013 Mar 1
22 23624790 Lipopolysaccharide-induced phosphorylation of c-Met tyrosine residue 1003 regulates c-Met intracellular trafficking and lung epithelial barrier function. 2013 Jul 1 5
23 23952536 Anti-c-MET Nanobody - a new potential drug in multiple myeloma treatment. 2013 Nov 1
24 23968581 3,3'-diindolylmethane rapidly and selectively inhibits hepatocyte growth factor/c-Met signaling in breast cancer cells. 2013 Nov 1
25 24081687 Herbacetin, a constituent of ephedrae herba, suppresses the HGF-induced motility of human breast cancer MDA-MB-231 cells by inhibiting c-Met and Akt phosphorylation. 2013 Nov 1
26 21163258 An adjacent arginine, and the phosphorylated tyrosine in the c-Met receptor target sequence, dictates the orientation of c-Cbl binding. 2011 Jan 21 2
27 21283737 Detection of hepatocyte growth factor (HGF) ligand-c-MET receptor activation in formalin-fixed paraffin embedded specimens by a novel proximity assay. 2011 Jan 21 6
28 21316260 Targeting phosphoinositide 3-kinase signalling in lung cancer. 2011 Nov 1
29 21423210 HGF-independent potentiation of EGFR action by c-Met. 2011 Aug 18 1
30 21734462 c-Met-Akt pathway-mediated enhancement of inhibitory c-Raf phosphorylation is involved in vitamin K1 and sorafenib synergy on HCC growth inhibition. 2011 Sep 15 1
31 21777671 Intracellular signaling cascades triggered by the NK1 fragment of hepatocyte growth factor in human prostate epithelial cell line PNT1A. 2011 Dec 2
32 20432459 Involvement of receptor tyrosine phosphatase DEP-1 mediated PI3K-cofilin signaling pathway in sorafenib-induced cytoskeletal rearrangement in hepatoma cells. 2010 Aug 1
33 20551596 The discovery of hepatocyte growth factor (HGF) and its significance for cell biology, life sciences and clinical medicine. 2010 1
34 20623641 The polyphenol epigallocatechin-3-gallate affects lipid rafts to block activation of the c-Met receptor in prostate cancer cells. 2010 Aug 1
35 19121849 Phosphorylated hepatocyte growth factor receptor/c-Met is associated with tumor growth and prognosis in patients with bladder cancer: correlation with matrix metalloproteinase-2 and -7 and E-cadherin. 2009 Apr 2
36 19375427 A bioactive drug quantitation based approach for the detection of anti-drug neutralizing antibodies in human serum. 2009 Jun 30 1
37 19403923 Development of a cell-based assay for measurement of c-Met phosphorylation using AlphaScreen technology and high-content imaging analysis. 2009 Apr 1
38 19240370 Synergism of EGFR and c-Met pathways, cross-talk and inhibition, in non-small cell lung cancer. 2008 1
39 17689859 CHM-1 inhibits hepatocyte growth factor-induced invasion of SK-Hep-1 human hepatocellular carcinoma cells by suppressing matrix metalloproteinase-9 expression. 2007 Nov 8 1
40 17689924 Lysophosphatidic acid modulates c-Met redistribution and hepatocyte growth factor/c-Met signaling in human bronchial epithelial cells through PKC delta and E-cadherin. 2007 Nov 1
41 18046719 Grb2-associated binder-1 plays a central role in the hepatocyte growth factor enhancement of hepatoma growth inhibition by K vitamin analog compound 5. 2007 Dec 2
42 16291834 hepatocyte growth factor is a downstream effector that mediates the antifibrotic action of peroxisome proliferator-activated receptor-gamma agonists. 2006 Jan 1
43 16415345 Contact inhibition of hepatocyte growth regulated by functional association of the c-Met/hepatocyte growth factor receptor and LAR protein-tyrosine phosphatase. 2006 Mar 31 6
44 16724983 Vascular endothelial growth factor protects hepatoma cells against oxidative stress-induced cell death. 2006 Jun 1
45 17062641 Tyrosine phosphorylation of p145met mediated by EGFR and Src is required for serum-independent survival of human bladder carcinoma cells. 2006 Nov 15 1
46 15839837 Hepatocyte growth factor is a preferred in vitro substrate for human hepsin, a membrane-anchored serine protease implicated in prostate and ovarian cancers. 2005 Aug 15 1
47 16227408 Knockdown of c-Met by adenovirus-delivered small interfering RNA inhibits hepatocellular carcinoma growth in vitro and in vivo. 2005 Oct 1
48 16237757 Lysophosphatidic acid transactivates both c-Met and epidermal growth factor receptor, and induces cyclooxygenase-2 expression in human colon cancer LoVo cells. 2005 Sep 28 2
49 15075332 Bi-directional regulation of Ser-985 phosphorylation of c-met via protein kinase C and protein phosphatase 2A involves c-Met activation and cellular responsiveness to hepatocyte growth factor. 2004 Jun 18 3
50 15187417 Enhancement of hepatocyte growth factor-induced cell scattering in N-acetylglucosaminyltransferase III-transfected HepG2 cells. 2004 Jun 1