Title : Tyrosine phosphorylation of RalGDS by c-Met receptor blocks its interaction with Ras.

Pub. Date : 2016 Nov 18

PMID : 27773821






2 Functional Relationships(s)
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1 Tyrosine phosphorylation of RalGDS by c-Met receptor blocks its interaction with Ras. Tyrosine MET proto-oncogene, receptor tyrosine kinase Homo sapiens
2 In this paper, we demonstrate a potential biochemical mechanism for such phenomena by showing that c-Met receptors promote the tyrosine phosphorylation of RalGDS at Y752 in its RBD, which blocks the binding of Ras to RalGDS. Tyrosine MET proto-oncogene, receptor tyrosine kinase Homo sapiens