Title : Contact inhibition of hepatocyte growth regulated by functional association of the c-Met/hepatocyte growth factor receptor and LAR protein-tyrosine phosphatase.

Pub. Date : 2006 Mar 31

PMID : 16415345






6 Functional Relationships(s)
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Protein Name
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1 In hepatocytes cultured at a sparse cell density, HGF stimulation induced prolonged c-Met tyrosine phosphorylation for over 5 h and a marked mitogenic response. Tyrosine MET proto-oncogene, receptor tyrosine kinase Homo sapiens
2 In contrast, HGF stimulation induced transient c-Met tyrosine phosphorylation in <3 h and failed to induce mitogenic response in hepatocytes cultured at a confluent cell density. Tyrosine MET proto-oncogene, receptor tyrosine kinase Homo sapiens
3 The mitogenic response to HGF was associated with the duration of c-Met tyrosine phosphorylation even in the sparse cells. Tyrosine MET proto-oncogene, receptor tyrosine kinase Homo sapiens
4 LAR and c-Met were associated, and purified LAR dephosphorylated tyrosine-phosphorylated c-Met in in vitro phosphatase reactions. Tyrosine MET proto-oncogene, receptor tyrosine kinase Homo sapiens
5 LAR and c-Met were associated, and purified LAR dephosphorylated tyrosine-phosphorylated c-Met in in vitro phosphatase reactions. Tyrosine MET proto-oncogene, receptor tyrosine kinase Homo sapiens
6 Furthermore, antisense oligonucleotides specific for LAR mRNA suppressed the expression of LAR, allowed prolonged c-Met tyrosine phosphorylation, and led to acquisition of a mitogenic response in hepatocytes even under the confluent condition. Tyrosine MET proto-oncogene, receptor tyrosine kinase Homo sapiens