Iron

iron-sulfur cluster assembly enzyme ; Homo sapiens







97 Article(s)
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51 23846788 Influence of microRNA on the maintenance of human iron metabolism. 2013 Jul 10 4
52 23909240 His86 from the N-terminus of frataxin coordinates iron and is required for Fe-S cluster synthesis. 2013 Sep 3 4
53 22125086 The defective splicing caused by the ISCU intron mutation in patients with myopathy with lactic acidosis is repressed by PTBP1 but can be derepressed by IGF2BP1. 2012 Mar 1
54 22155317 Antisense oligonucleotide corrects splice abnormality in hereditary myopathy with lactic acidosis. 2012 Feb 25 2
55 22896707 Micromanaging Iron Homeostasis: hypoxia-inducible micro-RNA-210 suppresses iron homeostasis-related proteins. 2012 Oct 5 1
56 23035118 Tissue specificity of a human mitochondrial disease: differentiation-enhanced mis-splicing of the Fe-S scaffold gene ISCU renders patient cells more sensitive to oxidative stress in ISCU myopathy. 2012 Nov 23 2
57 20957368 Expression, purification, and characterization of an iron chaperon protein CyaY from Acidithiobacillus ferrooxidans. 2011 Mar 2
58 21298097 Mammalian frataxin: an essential function for cellular viability through an interaction with a preformed ISCU/NFS1/ISD11 iron-sulfur assembly complex. 2011 Jan 26 1
59 21499539 Structural, Mechanistic and Coordination Chemistry of Relevance to the Biosynthesis of Iron-Sulfur and Related Iron Cofactors. 2011 Apr 1 2
60 21671584 Friedreich's ataxia variants I154F and W155R diminish frataxin-based activation of the iron-sulfur cluster assembly complex. 2011 Jul 26 1
61 21801864 miR-210 targets iron-sulfur cluster scaffold homologue in human trophoblast cell lines: siderosis of interstitial trophoblasts as a novel pathology of preterm preeclampsia and small-for-gestational-age pregnancies. 2011 Aug 2
62 21945528 Functional characterization of Fdx1: evidence for an evolutionary relationship between P450-type and ISC-type ferredoxins. 2011 Nov 11 1
63 21987576 Specialized function of yeast Isa1 and Isa2 proteins in the maturation of mitochondrial [4Fe-4S] proteins. 2011 Dec 2 1
64 20206689 Differences in RNA processing underlie the tissue specific phenotype of ISCU myopathy. 2010 Jun 2
65 20404999 Structural basis for Fe-S cluster assembly and tRNA thiolation mediated by IscS protein-protein interactions. 2010 Apr 13 2
66 20436681 MicroRNA-210 regulates mitochondrial free radical response to hypoxia and krebs cycle in cancer cells by targeting iron sulfur cluster protein ISCU. 2010 Apr 26 3
67 20481466 Human iron-sulfur cluster assembly, cellular iron homeostasis, and disease. 2010 Jun 22 1
68 20873749 Human frataxin is an allosteric switch that activates the Fe-S cluster biosynthetic complex. 2010 Nov 2 1
69 20981023 Structural bases for the interaction of frataxin with the central components of iron-sulphur cluster assembly. 2010 Oct 19 1
70 19308466 Iron-sulfur cluster biosynthesis: characterization of IscU-IscS complex formation and a structural model for sulfide delivery to the [2Fe-2S] assembly site. 2009 Aug 1
71 19462090 Iron-sulfur cluster biosynthesis: role of a semi-conserved histidine. 2009 Jun 7 1
72 19492851 Structure and dynamics of the iron-sulfur cluster assembly scaffold protein IscU and its interaction with the cochaperone HscB. 2009 Jul 7 2
73 19567699 Clinical manifestation and a new ISCU mutation in iron-sulphur cluster deficiency myopathy. 2009 Aug 5
74 19846308 Antisense oligonucleotide therapeutics for iron-sulphur cluster deficiency myopathy. 2009 Dec 1
75 18296749 Myopathy with lactic acidosis is linked to chromosome 12q23.3-24.11 and caused by an intron mutation in the ISCU gene resulting in a splicing defect. 2008 Jun 1 1
76 18304497 Splice mutation in the iron-sulfur cluster scaffold protein ISCU causes myopathy with exercise intolerance. 2008 Mar 9
77 18606475 Iron-sulfur cluster biogenesis and human disease. 2008 Aug 2
78 18986169 Studies on the mechanism of catalysis of iron-sulfur cluster transfer from IscU[2Fe2S] by HscA/HscB chaperones. 2008 Dec 2 5
79 17244611 Distinct iron binding property of two putative iron donors for the iron-sulfur cluster assembly: IscA and the bacterial frataxin ortholog CyaY under physiological and oxidative stress conditions. 2007 Mar 16 2
80 17331979 Mitochondrial frataxin interacts with ISD11 of the NFS1/ISCU complex and multiple mitochondrial chaperones. 2007 Apr 15 2
81 16517407 Functions of mitochondrial ISCU and cytosolic ISCU in mammalian iron-sulfur cluster biogenesis and iron homeostasis. 2006 Mar 5
82 16527810 Roles of the mammalian cytosolic cysteine desulfurase, ISCS, and scaffold protein, ISCU, in iron-sulfur cluster assembly. 2006 May 5 3
83 16603772 Iron-sulfur cluster biosynthesis: characterization of Escherichia coli CYaY as an iron donor for the assembly of [2Fe-2S] clusters in the scaffold IscU. 2006 Jun 16 2
84 15766257 Iron-sulfur cluster biosynthesis. Molecular chaperone DnaK promotes IscU-bound [2Fe-2S] cluster stability and inhibits cluster transfer activity. 2005 Mar 22 6
85 15815978 Structural characterization of an iron-sulfur cluster assembly protein IscU in a zinc-bound form. 2005 Jun 1 1
86 15828873 Mobilization of the iron centre in IscA for the iron-sulphur cluster assembly in IscU. 2005 Aug 1 2
87 14720122 Characterization of iron binding in IscA, an ancient iron-sulphur cluster assembly protein. 2004 Apr 15 7
88 14993221 Iron-sulfur cluster assembly: NifU-directed activation of the nitrogenase Fe protein. 2004 May 7 1
89 15143178 The yeast scaffold proteins Isu1p and Isu2p are required inside mitochondria for maturation of cytosolic Fe/S proteins. 2004 Jun 1
90 15247288 IscA mediates iron delivery for assembly of iron-sulfur clusters in IscU under the limited accessible free iron conditions. 2004 Sep 3 14
91 12756240 Ssq1, a mitochondrial Hsp70 involved in iron-sulfur (Fe/S) center biogenesis. Similarities to and differences from its bacterial counterpart. 2003 Aug 8 1
92 12886008 Subcellular compartmentalization of human Nfu, an iron-sulfur cluster scaffold protein, and its ability to assemble a [4Fe-4S] cluster. 2003 Aug 19 2
93 12137512 Iron-sulfur cluster biosynthesis: characterization of iron nucleation sites for assembly of the [2Fe-2S]2+ cluster core in IscU proteins. 2002 Jul 31 8
94 11686732 Sulfur transfer from IscS to IscU: the first step in iron-sulfur cluster biosynthesis. 2001 Nov 7 1
95 10891064 IscU as a scaffold for iron-sulfur cluster biosynthesis: sequential assembly of [2Fe-2S] and [4Fe-4S] clusters in IscU. 2000 Jul 11 4
96 11060020 Distinct iron-sulfur cluster assembly complexes exist in the cytosol and mitochondria of human cells. 2000 Nov 1 6
97 11123951 Characterization of the NifU and NifS Fe-S cluster formation proteins essential for viability in Helicobacter pylori. 2000 Dec 26 6