Title : Friedreich's ataxia variants I154F and W155R diminish frataxin-based activation of the iron-sulfur cluster assembly complex.

Pub. Date : 2011 Jul 26

PMID : 21671584






1 Functional Relationships(s)
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1 Together, these results suggest that Fxn facilitates sulfur transfer from Nfs1 to Isu2 and that these in vitro assays are sensitive and appropriate for deciphering functional defects and mechanistic details for human Fe-S cluster biosynthesis. Iron iron-sulfur cluster assembly enzyme Homo sapiens