Title : miR-210 targets iron-sulfur cluster scaffold homologue in human trophoblast cell lines: siderosis of interstitial trophoblasts as a novel pathology of preterm preeclampsia and small-for-gestational-age pregnancies.

Pub. Date : 2011 Aug

PMID : 21801864






2 Functional Relationships(s)
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1 RNA interference knockdown of ISCU expression in Swan 71, but not in BeWo, cells resulted in autophagosomal and siderosomal iron accumulation and a fourfold decrease of Matrigel invasion (P = 0.004). Iron iron-sulfur cluster assembly enzyme Homo sapiens
2 The findings herein suggest that ISCU down-regulation by miR-210 perturbing trophoblast iron metabolism is associated with defective placentation. Iron iron-sulfur cluster assembly enzyme Homo sapiens