Title : Enhanced ABL-inhibitor-induced MAPK-activation in T315I-BCR-ABL-expressing cells: a potential mechanism of altered leukemogenicity.

Pub. Date : 2012 Feb

PMID : 22089930






1 Functional Relationships(s)
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1 RESULTS: The ABL-inhibitors imatinib and nilotinib activate MAPKs in CD34+ chronic myelogenous leukemia progenitor cells, whereas treatment with the SRC/ABL-inhibitor dasatinib does not affect MAPK-activation at clinically relevant concentrations. Dasatinib ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens