Paclitaxel

cyclin dependent kinase inhibitor 1A ; Homo sapiens







30 Article(s)
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1 33436648 Integrative microRNA and gene expression analysis identifies new epigenetically regulated microRNAs mediating taxane resistance in ovarian cancer. 2021 Jan 12 1
2 31285951 Genome-scale CRISPR activation screening identifies a role of ELAVL2-CDKN1A axis in paclitaxel resistance in esophageal squamous cell carcinoma. 2019 2
3 24858045 Less understood issues: p21(Cip1) in mitosis and its therapeutic potential. 2015 Apr 2 1
4 25647149 Increased chemoresistance to paclitaxel in the MCF10AT series of human breast epithelial cancer cells. 2015 Apr 1
5 25912549 Low inducible expression of p21Cip1 confers resistance to paclitaxel in BRAF mutant melanoma cells with acquired resistance to BRAF inhibitor. 2015 Aug 11
6 26146988 CDK5 Regulates Paclitaxel Sensitivity in Ovarian Cancer Cells by Modulating AKT Activation, p21Cip1- and p27Kip1-Mediated G1 Cell Cycle Arrest and Apoptosis. 2015 2
7 26775347 Cytoplasmic p21 is responsible for paclitaxel resistance in ovarian cancer A2780 cells. 2015 8
8 23023313 Taxol-induced growth arrest and apoptosis is associated with the upregulation of the Cdk inhibitor, p21WAF1/CIP1, in human breast cancer cells. 2012 Dec 5
9 21822799 Cdk2 acts upstream of mitochondrial permeability transition during paclitaxel-induced apoptosis. 2011 Jul 2
10 22194993 Synergistic antitumor effects of novel HDAC inhibitors and paclitaxel in vitro and in vivo. 2011 2
11 20018861 Human GTSE-1 regulates p21(CIP1/WAF1) stability conferring resistance to paclitaxel treatment. 2010 Feb 19 6
12 20624405 Additive effects of C(2)-ceramide on paclitaxel-induced premature senescence of human lung cancer cells. 2010 Sep 11 1
13 20944098 The role of Akt activation in the response to chemotherapy in pancreatic cancer. 2010 Sep 1
14 19372587 ErbB2-mediated Src and signal transducer and activator of transcription 3 activation leads to transcriptional up-regulation of p21Cip1 and chemoresistance in breast cancer cells. 2009 Apr 4
15 18806740 Differential effects of low and high doses of Taxol in anaplastic thyroid cancer cells: possible implication of the Pin1 prolyl isomerase. 2008 Sep 2
16 16331265 Novel high-affinity PPARgamma agonist alone and in combination with paclitaxel inhibits human anaplastic thyroid carcinoma tumor growth via p21WAF1/CIP1. 2006 Apr 13 1
17 16432835 A p21/WAF1 mutation favors the appearance of drug resistance to paclitaxel in human noncancerous epithelial mammary cells. 2006 Jul 1 6
18 14985451 Gene expression correlating with response to paclitaxel in ovarian carcinoma xenografts. 2004 Feb 1
19 15467449 The cyclin-dependent kinase inhibitor p21(CIP1/WAF1) blocks paclitaxel-induced G2M arrest and attenuates mitochondrial injury and apoptosis in p53-null human leukemia cells. 2004 Oct 24
20 12574211 p21 Waf-1 (Cip-1) enhances apoptosis induced by manumycin and paclitaxel in anaplastic thyroid cancer cells. 2003 Feb 1
21 12684432 Low-dose fractionated radiation potentiates the effects of Paclitaxel in wild-type and mutant p53 head and neck tumor cell lines. 2003 Apr 1
22 12384528 Enhanced sensitization to taxol-induced apoptosis by herceptin pretreatment in ErbB2-overexpressing breast cancer cells. 2002 Oct 15 2
23 12432259 Flavopiridol inversely affects p21(WAF1/CIP1) and p53 and protects p21-sensitive cells from paclitaxel. 2002 Jul-Aug 2
24 12530065 Reduced expression of p53 and p21WAF1/CIP1 sensitizes human breast cancer cells to paclitaxel and its combination with 5-fluorouracil. 2002 Nov-Dec 5
25 11593424 Protection against chemotherapy-induced cytotoxicity by cyclin-dependent kinase inhibitors (CKI) in CKI-responsive cells compared with CKI-unresponsive cells. 2001 Sep 27 2
26 11034077 The phosphatidylinositol 3-kinase/AKT signal transduction pathway plays a critical role in the expression of p21WAF1/CIP1/SDI1 induced by cisplatin and paclitaxel. 2000 Oct 1 4
27 11045764 Adenoviral-mediated gene therapy with Ad5CMVp53 and Ad5CMVp21 in combination with standard therapies in human breast cancer cell lines. 2000 Oct 1
28 10347252 Overexpression of p21(waf1) decreases G2-M arrest and apoptosis induced by paclitaxel in human sarcoma cells lacking both p53 and functional Rb protein. 1999 Jun 8
29 9844631 Overexpression of ErbB2 blocks Taxol-induced apoptosis by upregulation of p21Cip1, which inhibits p34Cdc2 kinase. 1998 Nov 4
30 8763853 The interaction of taxol and vinblastine with radiation induction of p53 and p21 WAF1/CIP1. 1996 Jul 3