Title : Additive effects of C(2)-ceramide on paclitaxel-induced premature senescence of human lung cancer cells.

Pub. Date : 2010 Sep 11

PMID : 20624405






1 Functional Relationships(s)
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1 SIGNIFICANCE: our study demonstrates that the short-carbon chain C(2)-ceramide can effectively sensitize PTX-induced senescence of H1299 cells via both p21(waf1/cip1)- and p16(ink4)-independent pathways. Paclitaxel cyclin dependent kinase inhibitor 1A Homo sapiens