Pub. Date : 1999 Jun
PMID : 10347252
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Overexpression of p21(waf1) decreases G2-M arrest and apoptosis induced by paclitaxel in human sarcoma cells lacking both p53 and functional Rb protein. | Paclitaxel | cyclin dependent kinase inhibitor 1A | Homo sapiens |
| 2 | We examined the effect of overexpression of p21(waf1) on cytotoxicity of paclitaxel, a microtubule stabilizer, using a tetracycline-inducible expression system in human sarcoma cells (SaOs-2) that lack both functional retinoblastoma protein and p53. | Paclitaxel | cyclin dependent kinase inhibitor 1A | Homo sapiens |
| 3 | Upon p21(waf1) induction by tetracycline withdrawal, we observed a reduced apoptotic response to paclitaxel with a 3- to 6-fold increase in IC50 values compared with that of cells not induced by p21(waf1). | Paclitaxel | cyclin dependent kinase inhibitor 1A | Homo sapiens |
| 4 | After treatment with paclitaxel, less accumulation of G2-M was observed in p21(waf1)-induced cells compared with non-p21(waf1)-induced cells (57% versus 74%). | Paclitaxel | cyclin dependent kinase inhibitor 1A | Homo sapiens |
| 5 | After treatment with paclitaxel, less accumulation of G2-M was observed in p21(waf1)-induced cells compared with non-p21(waf1)-induced cells (57% versus 74%). | Paclitaxel | cyclin dependent kinase inhibitor 1A | Homo sapiens |
| 6 | p21(waf1) induction also inhibited the increased cyclin B1-associated kinase activity induced by paclitaxel. | Paclitaxel | cyclin dependent kinase inhibitor 1A | Homo sapiens |
| 7 | Overexpression of p21(waf1) in SaOs-2 cells lacking both p53 and functional retinoblastoma protein may decrease the G2-M arrest induced by paclitaxel due to suppression of the S-G2 checkpoint, resulting in a decreased apoptotic response of cells to paclitaxel. | Paclitaxel | cyclin dependent kinase inhibitor 1A | Homo sapiens |
| 8 | Overexpression of p21(waf1) in SaOs-2 cells lacking both p53 and functional retinoblastoma protein may decrease the G2-M arrest induced by paclitaxel due to suppression of the S-G2 checkpoint, resulting in a decreased apoptotic response of cells to paclitaxel. | Paclitaxel | cyclin dependent kinase inhibitor 1A | Homo sapiens |