Pub. Date : 2004 Oct
PMID : 15467449
24 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The cyclin-dependent kinase inhibitor p21(CIP1/WAF1) blocks paclitaxel-induced G2M arrest and attenuates mitochondrial injury and apoptosis in p53-null human leukemia cells. | Paclitaxel | cyclin dependent kinase inhibitor 1A | Homo sapiens |
| 2 | The cyclin-dependent kinase inhibitor p21(CIP1/WAF1) blocks paclitaxel-induced G2M arrest and attenuates mitochondrial injury and apoptosis in p53-null human leukemia cells. | Paclitaxel | cyclin dependent kinase inhibitor 1A | Homo sapiens |
| 3 | The cyclin-dependent kinase inhibitor p21(CIP1/WAF1) blocks paclitaxel-induced G2M arrest and attenuates mitochondrial injury and apoptosis in p53-null human leukemia cells. | Paclitaxel | cyclin dependent kinase inhibitor 1A | Homo sapiens |
| 4 | The functional significance of the cyclin-dependent kinase inhibitor (CDKI) p21(Cip1/WAF1) in paclitaxel-mediated lethality was examined in p53-null human leukemia cells (U937 and Jurkat). | Paclitaxel | cyclin dependent kinase inhibitor 1A | Homo sapiens |
| 5 | The functional significance of the cyclin-dependent kinase inhibitor (CDKI) p21(Cip1/WAF1) in paclitaxel-mediated lethality was examined in p53-null human leukemia cells (U937 and Jurkat). | Paclitaxel | cyclin dependent kinase inhibitor 1A | Homo sapiens |
| 6 | The functional significance of the cyclin-dependent kinase inhibitor (CDKI) p21(Cip1/WAF1) in paclitaxel-mediated lethality was examined in p53-null human leukemia cells (U937 and Jurkat). | Paclitaxel | cyclin dependent kinase inhibitor 1A | Homo sapiens |
| 7 | Nevertheless, stable expression of U937 cells with a p21(Cip1/WAF1) antisense construct blocked paclitaxel-induced G(2)M arrest and increased mitochondrial injury, caspase activation, apoptosis, and loss of clonogenic potential. | Paclitaxel | cyclin dependent kinase inhibitor 1A | Homo sapiens |
| 8 | Nevertheless, stable expression of U937 cells with a p21(Cip1/WAF1) antisense construct blocked paclitaxel-induced G(2)M arrest and increased mitochondrial injury, caspase activation, apoptosis, and loss of clonogenic potential. | Paclitaxel | cyclin dependent kinase inhibitor 1A | Homo sapiens |
| 9 | Nevertheless, stable expression of U937 cells with a p21(Cip1/WAF1) antisense construct blocked paclitaxel-induced G(2)M arrest and increased mitochondrial injury, caspase activation, apoptosis, and loss of clonogenic potential. | Paclitaxel | cyclin dependent kinase inhibitor 1A | Homo sapiens |
| 10 | Consistent with these results, enforced expression of p21(Cip1/WAF1) in Jurkat cells increased the percentage of cells arrested in G2M and attenuated paclitaxel-mediated mitochondrial injury and apoptosis. | Paclitaxel | cyclin dependent kinase inhibitor 1A | Homo sapiens |
| 11 | Consistent with these results, enforced expression of p21(Cip1/WAF1) in Jurkat cells increased the percentage of cells arrested in G2M and attenuated paclitaxel-mediated mitochondrial injury and apoptosis. | Paclitaxel | cyclin dependent kinase inhibitor 1A | Homo sapiens |
| 12 | Consistent with these results, enforced expression of p21(Cip1/WAF1) in Jurkat cells increased the percentage of cells arrested in G2M and attenuated paclitaxel-mediated mitochondrial injury and apoptosis. | Paclitaxel | cyclin dependent kinase inhibitor 1A | Homo sapiens |
| 13 | Unexpectedly, enforced expression of p21(Cip1/WAF1) diminished paclitaxel-mediated inactivation of ERK, and reduced paclitaxel-induced activation of JNK as well as Bcl-2 phosphorylation. | Paclitaxel | cyclin dependent kinase inhibitor 1A | Homo sapiens |
| 14 | Unexpectedly, enforced expression of p21(Cip1/WAF1) diminished paclitaxel-mediated inactivation of ERK, and reduced paclitaxel-induced activation of JNK as well as Bcl-2 phosphorylation. | Paclitaxel | cyclin dependent kinase inhibitor 1A | Homo sapiens |
| 15 | Unexpectedly, enforced expression of p21(Cip1/WAF1) diminished paclitaxel-mediated inactivation of ERK, and reduced paclitaxel-induced activation of JNK as well as Bcl-2 phosphorylation. | Paclitaxel | cyclin dependent kinase inhibitor 1A | Homo sapiens |
| 16 | Unexpectedly, enforced expression of p21(Cip1/WAF1) diminished paclitaxel-mediated inactivation of ERK, and reduced paclitaxel-induced activation of JNK as well as Bcl-2 phosphorylation. | Paclitaxel | cyclin dependent kinase inhibitor 1A | Homo sapiens |
| 17 | Unexpectedly, enforced expression of p21(Cip1/WAF1) diminished paclitaxel-mediated inactivation of ERK, and reduced paclitaxel-induced activation of JNK as well as Bcl-2 phosphorylation. | Paclitaxel | cyclin dependent kinase inhibitor 1A | Homo sapiens |
| 18 | Unexpectedly, enforced expression of p21(Cip1/WAF1) diminished paclitaxel-mediated inactivation of ERK, and reduced paclitaxel-induced activation of JNK as well as Bcl-2 phosphorylation. | Paclitaxel | cyclin dependent kinase inhibitor 1A | Homo sapiens |
| 19 | Together, these findings suggest that p21(Cip1/WAF1) partially protects p53-null human leukemia cells from paclitaxel-mediated lethality, and raise the possibility that p21(Cip1/WAF1)-associated perturbations in signal transduction pathways as well as Bcl-2 phosphorylation status may play a role in this phenomenon. | Paclitaxel | cyclin dependent kinase inhibitor 1A | Homo sapiens |
| 20 | Together, these findings suggest that p21(Cip1/WAF1) partially protects p53-null human leukemia cells from paclitaxel-mediated lethality, and raise the possibility that p21(Cip1/WAF1)-associated perturbations in signal transduction pathways as well as Bcl-2 phosphorylation status may play a role in this phenomenon. | Paclitaxel | cyclin dependent kinase inhibitor 1A | Homo sapiens |
| 21 | Together, these findings suggest that p21(Cip1/WAF1) partially protects p53-null human leukemia cells from paclitaxel-mediated lethality, and raise the possibility that p21(Cip1/WAF1)-associated perturbations in signal transduction pathways as well as Bcl-2 phosphorylation status may play a role in this phenomenon. | Paclitaxel | cyclin dependent kinase inhibitor 1A | Homo sapiens |
| 22 | Together, these findings suggest that p21(Cip1/WAF1) partially protects p53-null human leukemia cells from paclitaxel-mediated lethality, and raise the possibility that p21(Cip1/WAF1)-associated perturbations in signal transduction pathways as well as Bcl-2 phosphorylation status may play a role in this phenomenon. | Paclitaxel | cyclin dependent kinase inhibitor 1A | Homo sapiens |
| 23 | Together, these findings suggest that p21(Cip1/WAF1) partially protects p53-null human leukemia cells from paclitaxel-mediated lethality, and raise the possibility that p21(Cip1/WAF1)-associated perturbations in signal transduction pathways as well as Bcl-2 phosphorylation status may play a role in this phenomenon. | Paclitaxel | cyclin dependent kinase inhibitor 1A | Homo sapiens |
| 24 | Together, these findings suggest that p21(Cip1/WAF1) partially protects p53-null human leukemia cells from paclitaxel-mediated lethality, and raise the possibility that p21(Cip1/WAF1)-associated perturbations in signal transduction pathways as well as Bcl-2 phosphorylation status may play a role in this phenomenon. | Paclitaxel | cyclin dependent kinase inhibitor 1A | Homo sapiens |