Pub. Date : 2015 Aug
PMID : 25912549
11 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Low inducible expression of p21Cip1 confers resistance to paclitaxel in BRAF mutant melanoma cells with acquired resistance to BRAF inhibitor. | Paclitaxel | cyclin dependent kinase inhibitor 1A | Homo sapiens |
| 2 | In A375P cells, paclitaxel treatment resulted in a marked emergence of apoptotic cells after mitotic arrest, concomitant with a remarkable induction of p21(Cip1). | Paclitaxel | cyclin dependent kinase inhibitor 1A | Homo sapiens |
| 3 | In A375P cells, paclitaxel treatment resulted in a marked emergence of apoptotic cells after mitotic arrest, concomitant with a remarkable induction of p21(Cip1). | Paclitaxel | cyclin dependent kinase inhibitor 1A | Homo sapiens |
| 4 | However, paclitaxel only moderately increased the levels of p21(Cip1) in A375P/Mdr cells, which exhibited a strong resistance to paclitaxel. | Paclitaxel | cyclin dependent kinase inhibitor 1A | Homo sapiens |
| 5 | However, paclitaxel only moderately increased the levels of p21(Cip1) in A375P/Mdr cells, which exhibited a strong resistance to paclitaxel. | Paclitaxel | cyclin dependent kinase inhibitor 1A | Homo sapiens |
| 6 | However, paclitaxel only moderately increased the levels of p21(Cip1) in A375P/Mdr cells, which exhibited a strong resistance to paclitaxel. | Paclitaxel | cyclin dependent kinase inhibitor 1A | Homo sapiens |
| 7 | However, paclitaxel only moderately increased the levels of p21(Cip1) in A375P/Mdr cells, which exhibited a strong resistance to paclitaxel. | Paclitaxel | cyclin dependent kinase inhibitor 1A | Homo sapiens |
| 8 | The p21(Cip1) overexpression partially conferred paclitaxel sensitivity to A375P/Mdr cells. | Paclitaxel | cyclin dependent kinase inhibitor 1A | Homo sapiens |
| 9 | The p21(Cip1) overexpression partially conferred paclitaxel sensitivity to A375P/Mdr cells. | Paclitaxel | cyclin dependent kinase inhibitor 1A | Homo sapiens |
| 10 | Taken together, these results suggest that paclitaxel may be an effective anticancer agent through regulating the expression of p21(Cip1) for the treatment of BRAF mutant melanoma cells resistant to BRAF inhibitors. | Paclitaxel | cyclin dependent kinase inhibitor 1A | Homo sapiens |
| 11 | Taken together, these results suggest that paclitaxel may be an effective anticancer agent through regulating the expression of p21(Cip1) for the treatment of BRAF mutant melanoma cells resistant to BRAF inhibitors. | Paclitaxel | cyclin dependent kinase inhibitor 1A | Homo sapiens |