Pub. Date : 1998 Nov
PMID : 9844631
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Overexpression of ErbB2 blocks Taxol-induced apoptosis by upregulation of p21Cip1, which inhibits p34Cdc2 kinase. | Paclitaxel | cyclin dependent kinase inhibitor 1A | Homo sapiens |
| 2 | Overexpression of p185ErbB2 in MDA-MB-435 cells by transfection transcriptionally upregulates p21Cip1, which associates with p34Cdc2, inhibits Taxol-mediated p34Cdc2 activation, delays cell entrance to G2/M phase, and thereby inhibits Taxol-induced apoptosis. | Paclitaxel | cyclin dependent kinase inhibitor 1A | Homo sapiens |
| 3 | Overexpression of p185ErbB2 in MDA-MB-435 cells by transfection transcriptionally upregulates p21Cip1, which associates with p34Cdc2, inhibits Taxol-mediated p34Cdc2 activation, delays cell entrance to G2/M phase, and thereby inhibits Taxol-induced apoptosis. | Paclitaxel | cyclin dependent kinase inhibitor 1A | Homo sapiens |
| 4 | Therefore, p21Cip1 participates in the regulation of a G2/M checkpoint that contributes to resistance to Taxol-induced apoptosis in p185ErbB2-overexpressing breast cancer cells. | Paclitaxel | cyclin dependent kinase inhibitor 1A | Homo sapiens |