Title : Cdk2 acts upstream of mitochondrial permeability transition during paclitaxel-induced apoptosis.

Pub. Date : 2011 Jul

PMID : 21822799






2 Functional Relationships(s)
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Protein Name
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1 Ectopic expression of the dominant negative Cdk2 (Cdk2-dn) and a specific Cdk2 inhibitor, p21( WAF1/CIP1 ), effectively suppresses the loss of MMP, the release of cytochrome c, and subsequent activation of caspase-3 in paclitaxel-treated cells. Paclitaxel cyclin dependent kinase inhibitor 1A Homo sapiens
2 Ectopic expression of the dominant negative Cdk2 (Cdk2-dn) and a specific Cdk2 inhibitor, p21( WAF1/CIP1 ), effectively suppresses the loss of MMP, the release of cytochrome c, and subsequent activation of caspase-3 in paclitaxel-treated cells. Paclitaxel cyclin dependent kinase inhibitor 1A Homo sapiens