Cholesterol

sterol regulatory element binding transcription factor 2 ; Homo sapiens







237 Article(s)
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1 33677747 SREBF2 triggers endoplasmic reticulum stress and Bax dysregulation to promote lipopolysaccharide-induced endothelial cell injury. 2022 Feb 1
2 34384758 RORγ is a context-specific master regulator of cholesterol biosynthesis and an emerging therapeutic target in cancer and autoimmune diseases. 2022 Feb 1
3 34739188 Fine-Tuning of Cholesterol Homeostasis Controls Erythroid Differentiation. 2022 Jan 4
4 34811795 Neurotherapeutic implications of sense and respond strategies generated by astrocytes and astrocytic tumours to combat pH mechanical stress. 2022 Feb 1
5 34893975 Flaxseed-derived peptide, IPPF, inhibits intestinal cholesterol absorption in Caco-2 cells and hepatic cholesterol synthesis in HepG2 cells. 2022 Jan 1
6 35140212 Caffeine blocks SREBP2-induced hepatic PCSK9 expression to enhance LDLR-mediated cholesterol clearance. 2022 Feb 9 1
7 35145111 Copy number amplification of ENSA promotes the progression of triple-negative breast cancer via cholesterol biosynthesis. 2022 Feb 10 4
8 35151688 Exosomal miR-673-5p from fibroblasts promotes Schwann cell-mediated peripheral neuron myelination by targeting the TSC2/mTORC1/SREBP2 axis. 2022 Mar 1
9 35276852 Assessment of the Cholesterol-Lowering Effect of MOMAST®: Biochemical and Cellular Studies. 2022 Jan 23 1
10 35369058 Aberrant Cholesterol Metabolic Genes Regulation in a Negative Feedback Loop Induced by an Alphacoronavirus. 2022 2
11 35386468 Black TiO2 nanoprobe-mediated mild phototherapy reduces intracellular lipid levels in atherosclerotic foam cells via cholesterol regulation pathways instead of apoptosis. 2022 Nov 2
12 35408842 Targeting Protein Translation in Melanoma by Inhibiting EEF-2 Kinase Regulates Cholesterol Metabolism though SREBP2 to Inhibit Tumour Development. 2022 Mar 23 3
13 35495674 LncRNA NEAT1 Potentiates SREBP2 Activity to Promote Inflammatory Macrophage Activation and Limit Hantaan Virus Propagation. 2022 1
14 35568729 TDP-43 regulates cholesterol biosynthesis by inhibiting sterol regulatory element-binding protein 2. 2022 May 14 3
15 35585420 Retinoic acid increases the cellular cholesterol predominantly in a mTOR-independent manner. 2022 May 18 2
16 35595819 Aberrant cholesterol metabolic signaling impairs antitumor immunosurveillance through natural killer T cell dysfunction in obese liver. 2022 May 20 2
17 35619540 KIF11 manipulates SREBP2-dependent mevalonate cross talk to promote tumor progression in pancreatic ductal adenocarcinoma. 2022 May 26 1
18 35625914 A Very Rare Variant in SREBF2, a Possible Cause of Hypercholesterolemia and Increased Glycemic Levels. 2022 May 19 1
19 33234676 BRD2 regulation of sigma-2 receptor upon cholesterol deprivation. 2021 Jan 1
20 33414447 MIEF2 reprograms lipid metabolism to drive progression of ovarian cancer through ROS/AKT/mTOR signaling pathway. 2021 Jan 5 4
21 33459178 The prorenin receptor and its soluble form contribute to lipid homeostasis. 2021 Mar 1 1
22 33473285 Curcumin inhibits the proteolytic process of SREBP-2 by first inhibiting the expression of S1P rather than directly inhibiting SREBP-2 expression. 2021 Jan 1
23 33687065 Activation of pregnane X receptor induces atherogenic lipids and PCSK9 by a SREBP2-mediated mechanism. 2021 Jun 1
24 33787903 Impact of high fat diet on the sterol regulatory element-binding protein 2 cholesterol pathway in the testicle. 2021 May 8 1
25 33974044 SREBP2 gene therapy targeting striatal astrocytes ameliorates Huntington's disease phenotypes. 2021 Nov 29 1
26 33995676 Organ-specific cholesterol metabolic aberration fuels liver metastasis of colorectal cancer. 2021 5
27 34093212 Maprotiline Suppresses Cholesterol Biosynthesis and Hepatocellular Carcinoma Progression Through Direct Targeting of CRABP1. 2021 2
28 34225017 Selective estrogen receptor modulators (SERMs) affect cholesterol homeostasis through the master regulators SREBP and LXR. 2021 Sep 1
29 34347016 TDP-43 mediates SREBF2-regulated gene expression required for oligodendrocyte myelination. 2021 Sep 6 2
30 34480898 Iron loading induces cholesterol synthesis and sensitizes endothelial cells to TNFα-mediated apoptosis. 2021 Oct 1
31 34516695 Tissue cholesterol metabolism and prostate cancer aggressiveness: Ethno-geographic variations. 2021 Dec 1
32 34667945 NRF3 upregulates gene expression in SREBP2-dependent mevalonate pathway with cholesterol uptake and lipogenesis inhibition. 2021 Oct 22 1
33 34686466 Berberine mitigates nonalcoholic hepatic steatosis by downregulating SIRT1-FoxO1-SREBP2 pathway for cholesterol synthesis. 2021 Nov 1
34 34750386 MMAB promotes negative feedback control of cholesterol homeostasis. 2021 Nov 8 2
35 34790132 SOAT1 Promotes Gastric Cancer Lymph Node Metastasis Through Lipid Synthesis. 2021 1
36 34804919 TFCP2 Overcomes Senescence by Cooperating With SREBP2 to Activate Cholesterol Synthesis in Pancreatic Cancer. 2021 3
37 31417158 Selective Ah receptor modulators attenuate NPC1L1-mediated cholesterol uptake through repression of SREBP-2 transcriptional activity. 2020 Feb 2
38 31770510 Cholesterol in LDL receptor recycling and degradation. 2020 Jan 1
39 31907393 Dual targeting of SREBP2 and ERRα by carnosic acid suppresses RANKL-mediated osteoclastogenesis and prevents ovariectomy-induced bone loss. 2020 Jul 2
40 31932581 SIK2 enhances synthesis of fatty acid and cholesterol in ovarian cancer cells and tumor growth through PI3K/Akt signaling pathway. 2020 Jan 13 2
41 31978555 Molecular and cellular insights into the role of SND1 in lipid metabolism. 2020 May 2
42 32028644 EHMT2 Inhibition Induces Cell Death in Human Non-Small Cell Lung Cancer by Altering the Cholesterol Biosynthesis Pathway. 2020 Feb 3 1
43 32054686 Ring finger protein 5 activates sterol regulatory element-binding protein 2 (SREBP2) to promote cholesterol biosynthesis via inducing polyubiquitination of SREBP chaperone SCAP. 2020 Mar 20 4
44 32161285 NBEAL1 controls SREBP2 processing and cholesterol metabolism and is a susceptibility locus for coronary artery disease. 2020 Mar 11 2
45 32184642 Loss of HNF1α Function Contributes to Hepatocyte Proliferation and Abnormal Cholesterol Metabolism via Downregulating miR-122: A Novel Mechanism of MODY3. 2020 2
46 32229726 Serine-threonine kinase ROCK2 regulates germinal center B cell positioning and cholesterol biosynthesis. 2020 Jul 1 2
47 32241558 Transthyretin Regulated by linc00657/miR-205-5p Promoted Cholesterol Metabolism by Inducing SREBP2-HMGCR and Inhibiting LXRα-CYP7A1. 2020 May 2
48 32258442 Spermine synthesis inhibitor blocks 25-hydroxycholesterol-induced- apoptosis via SREBP2 upregulation in DLD-1 cell spheroids. 2020 Jul 2
49 32580085 Ubiquitin-mediated regulation of sterol homeostasis. 2020 Aug 1
50 32719109 Aster Proteins Regulate the Accessible Cholesterol Pool in the Plasma Membrane. 2020 Sep 14 3