Pub. Date : 2021
PMID : 33995676
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The role of SREBP2-dependent cholesterol biosynthesis pathway in cell growth and CRC liver metastasis were determined by SREBP2 silencing in CRC cell lines and experimental metastasis models including, intra-splenic injection models and liver orthotropic injection model. | Cholesterol | sterol regulatory element binding transcription factor 2 | Homo sapiens |
| 2 | The role of SREBP2-dependent cholesterol biosynthesis pathway in cell growth and CRC liver metastasis were determined by SREBP2 silencing in CRC cell lines and experimental metastasis models including, intra-splenic injection models and liver orthotropic injection model. | Cholesterol | sterol regulatory element binding transcription factor 2 | Homo sapiens |
| 3 | Results: In the present study, we identify a colorectal cancer (CRC) liver metastasis-specific cholesterol metabolic pathway involving the activation of SREBP2-dependent cholesterol biosynthesis, which is required for the colonization and growth of metastatic CRC cells in the liver. | Cholesterol | sterol regulatory element binding transcription factor 2 | Homo sapiens |
| 4 | Results: In the present study, we identify a colorectal cancer (CRC) liver metastasis-specific cholesterol metabolic pathway involving the activation of SREBP2-dependent cholesterol biosynthesis, which is required for the colonization and growth of metastatic CRC cells in the liver. | Cholesterol | sterol regulatory element binding transcription factor 2 | Homo sapiens |
| 5 | Mechanically, hepatocyte growth factor (HGF) from liver environment activates SREBP2-dependent cholesterol biosynthesis pathway by activating c-Met/PI3K/AKT/mTOR axis in CRC cells. | Cholesterol | sterol regulatory element binding transcription factor 2 | Homo sapiens |