Title : TDP-43 mediates SREBF2-regulated gene expression required for oligodendrocyte myelination.

Pub. Date : 2021 Sep 6

PMID : 34347016






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 TDP-43 binds directly to mRNA of SREBF2, the master transcription regulator for cholesterol metabolism, and multiple mRNAs encoding proteins responsible for cholesterol biosynthesis and uptake, including HMGCR, HMGCS1, and LDLR. Cholesterol sterol regulatory element binding transcription factor 2 Homo sapiens
2 TDP-43-mediated changes in cholesterol levels can be restored by reintroducing SREBF2 or LDLR. Cholesterol sterol regulatory element binding transcription factor 2 Homo sapiens