Title : Neurotherapeutic implications of sense and respond strategies generated by astrocytes and astrocytic tumours to combat pH mechanical stress.

Pub. Date : 2022 Feb

PMID : 34811795






1 Functional Relationships(s)
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Protein Name
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1 GM3 acts as a lipid-based pH sensor, and in low pHe, its highly protonated state generates plasma membrane deformation stress which activates the IRE1-sXBP1-SREBP2-ACSS2 response axis for cholesterol biosynthesis and surface trafficking. Cholesterol sterol regulatory element binding transcription factor 2 Homo sapiens