Pub. Date : 2021
PMID : 34804919
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | TFCP2 Overcomes Senescence by Cooperating With SREBP2 to Activate Cholesterol Synthesis in Pancreatic Cancer. | Cholesterol | sterol regulatory element binding transcription factor 2 | Homo sapiens |
| 2 | Mechanistically, the interaction between TFCP2 and SREBP2 (sterol regulatory element binding transcription factor 2) synergistically activated the expression of HMGCR, a rate-limiting enzyme in cholesterol synthesis, and statins could reverse the inhibitory effect of TFCP2 on senescence. | Cholesterol | sterol regulatory element binding transcription factor 2 | Homo sapiens |
| 3 | Mechanistically, the interaction between TFCP2 and SREBP2 (sterol regulatory element binding transcription factor 2) synergistically activated the expression of HMGCR, a rate-limiting enzyme in cholesterol synthesis, and statins could reverse the inhibitory effect of TFCP2 on senescence. | Cholesterol | sterol regulatory element binding transcription factor 2 | Homo sapiens |