| 1 |
34175342 | Sildenafil in ophthalmology: An update. | 2022 Mar-Apr |
1 |
| 2 |
34875337 | Phosphodiesterase (PDE) 5 inhibitors sildenafil, tadalafil and vardenafil impact cAMP-specific PDE8 isoforms-linked second messengers and steroid production in a mouse Leydig tumor cell line. | 2022 Feb 15 |
2 |
| 3 |
34984916 | Sildenafil (Viagra) Aggravates the Development of Experimental Abdominal Aortic Aneurysm. | 2022 Jan 18 |
1 |
| 4 |
35050491 | How do phosphodiesterase-5 inhibitors affect cancer? A focus on glioblastoma multiforme. | 2022 Apr |
2 |
| 5 |
35119252 | Effects of Tadalafil on skeletal muscle tissue: exploring interactions and novel mechanisms of action. | 2022 Feb 4 |
1 |
| 6 |
35163827 | A Real-Time, Plate-Based BRET Assay for Detection of cGMP in Primary Cells. | 2022 Feb 8 |
1 |
| 7 |
35369720 | Mechanisms of Action of a Herbal Formula Huangqi Guizhi Wuwu Tang for the Management of Post-Stroke Related Numbness and Weakness: A Computational Molecular Docking Study. | 2022 Jan-Dec |
2 |
| 8 |
32526061 | Targeting the NO-cGMP-PDE5 pathway in COVID-19 infection. The DEDALO project. | 2021 Jan |
2 |
| 9 |
32964819 | Repurposing of the PDE5 Inhibitor Sildenafil for the Treatment of Persistent Pulmonary Hypertension in Neonates. | 2021 |
4 |
| 10 |
33348311 | Phosphodiesterase 5 (PDE5): Structure-function regulation and therapeutic applications of inhibitors. | 2021 Feb |
3 |
| 11 |
33572094 | Multifunctional Isosteric Pyridine Analogs-Based 2-Aminothiazole: Design, Synthesis, and Potential Phosphodiesterase-5 Inhibitory Activity. | 2021 Feb 9 |
1 |
| 12 |
33718200 | New Approaches in Oncology for Repositioning Drugs: The Case of PDE5 Inhibitor Sildenafil. | 2021 |
2 |
| 13 |
33741394 | Sildenafil prevents HDACi-induced Epstein-Barr virus reactivation through the PKG pathway in NK/T cell lymphoma; potential implications for HDACi-mediated fatal complications. | 2021 May |
1 |
| 14 |
33809319 | Visual Side Effects Linked to Sildenafil Consumption: An Update. | 2021 Mar 12 |
4 |
| 15 |
34393818 | Treatment of Cardiovascular Dysfunction With PDE5-Inhibitors - Temperature Dependent Effects on Transport and Metabolism of cAMP and cGMP. | 2021 |
1 |
| 16 |
34471575 | Is Tadalafil an Effective Treatment Option for Interstitial Cystitis/Painful Bladder Syndrome? A Report of a Challenging Case. | 2021 Jul |
4 |
| 17 |
34471776 | On the Viability of Tadalafil-Based 18F-Radiotracers for In Vivo Phosphodiesterase 5 (PDE5) PET Imaging. | 2021 Aug 24 |
3 |
| 18 |
34507030 | Priming metabolism with the type 5 phosphodiesterase: the role of cGMP-hydrolyzing enzymes. | 2021 Oct |
1 |
| 19 |
34638713 | Cyclic GMP in Liver Cirrhosis-Role in Pathophysiology of Portal Hypertension and Therapeutic Implications. | 2021 Sep 26 |
5 |
| 20 |
34727793 | First molecular modelling report on tri-substituted pyrazolines as phosphodiesterase 5 (PDE5) inhibitors through classical and machine learning based multi-QSAR analysis. | 2021 Nov |
4 |
| 21 |
34820318 | Preparation and physicochemical characterization of sildenafil cocrystals. | 2021 Oct-Dec |
3 |
| 22 |
32191546 | Mechanisms underlying priapism in sickle cell disease: targeting and key innovations on the preclinical landscape. | 2020 May |
1 |
| 23 |
32215350 | Estrogen Receptor-α Non-Nuclear Signaling Confers Cardioprotection and Is Essential to cGMP-PDE5 Inhibition Efficacy. | 2020 Mar |
1 |
| 24 |
32229414 | Identification and experimental confirmation of novel cGMP efflux inhibitors by virtual ligand screening of vardenafil-analogues. | 2020 Jun |
2 |
| 25 |
32231130 | Burn-Induced Cardiac Mitochondrial Dysfunction via Interruption of the PDE5A-cGMP-PKG Pathway. | 2020 Mar 28 |
4 |
| 26 |
32427079 | Nitric Oxide Donors as Potential Drugs for the Treatment of Vascular Diseases Due to Endothelium Dysfunction. | 2020 |
1 |
| 27 |
32454444 | Prostate Cancer Cell Phenotypes Remain Stable Following PDE5 Inhibition in the Clinically Relevant Range. | 2020 Sep |
3 |
| 28 |
32467879 | Sildenafil for the Treatment of Alzheimer's Disease: A Systematic Review. | 2020 Apr 22 |
2 |
| 29 |
32534033 | Tadalafil versus linaclotide in gastrointestinal dysfunction and depressive behavior in constipation-predominant irritable bowel syndrome. | 2020 Sep 1 |
2 |
| 30 |
32562844 | PDE5 and PDE10 inhibition activates cGMP/PKG signaling to block Wnt/β-catenin transcription, cancer cell growth, and tumor immunity. | 2020 Aug |
2 |
| 31 |
32628940 | Type 5 phosphodiesterase (PDE5) and the vascular tree: From embryogenesis to aging and disease. | 2020 Sep |
1 |
| 32 |
32872119 | Phosphodiesterases in the Liver as Potential Therapeutic Targets of Cirrhotic Portal Hypertension. | 2020 Aug 28 |
3 |
| 33 |
30189250 | Targeting the paracrine hormone-dependent guanylate cyclase/cGMP/phosphodiesterases signaling pathway for colorectal cancer prevention. | 2019 Jun |
1 |
| 34 |
30258189 | The two phases of the clinical validation of preclinical translational mechanistic research on PDE5 inhibitors since Viagra's advent. A personal perspective. | 2019 Mar |
1 |
| 35 |
30350485 | No Causal Link between Phosphodiesterase Type 5 Inhibition and Melanoma. | 2019 Sep |
2 |
| 36 |
30381900 | Q817G mutation in phosphodiesterase type 5: Conformational analysis and dissociation profile of the inhibitor Tadalafil. | 2019 Apr |
4 |
| 37 |
30388886 | Hydroalcoholic Extract of Levisticum officinale Increases cGMP Signaling Pathway by Down-Regulating PDE5 Expression and Induction of Apoptosis in MCF-7 and MDA-MB-468 Breast Cancer Cell Lines | 2019 Jul |
2 |
| 38 |
30590671 | The cGMP-Degrading Enzyme Phosphodiesterase-5 (PDE5) in Cerebral Small Arteries of Older People. | 2019 Feb 1 |
2 |
| 39 |
30747070 | Novel Pyrazolo[4, 3-c]Quinolin-3-One Derivatives as PDE5A Inhibitors. | 2019 |
1 |
| 40 |
30761523 | Neprilysin inhibition for pulmonary arterial hypertension: a randomized, double-blind, placebo-controlled, proof-of-concept trial. | 2019 May |
1 |
| 41 |
30958912 | Activation of cGMP/PKG/p65 signaling associated with PDE5-Is downregulates CCL5 secretion by CD8 + T cells in benign prostatic hyperplasia. | 2019 Jun |
4 |
| 42 |
31248114 | Biphasic Effect of Sildenafil on Energy Sensing is Mediated by Phosphodiesterases 2 and 3 in Adipocytes and Hepatocytes. | 2019 Jun 19 |
2 |
| 43 |
31248451 | Synaptic and memory dysfunction induced by tau oligomers is rescued by up-regulation of the nitric oxide cascade. | 2019 Jun 27 |
3 |
| 44 |
31434939 | Regulation of PDE5 expression in human aorta and thoracic aortic aneurysms. | 2019 Aug 21 |
2 |
| 45 |
28213937 | Targeting phosphodiesterase 5 as a therapeutic option against myocardial ischaemia/reperfusion injury and for treating heart failure. | 2018 Jan |
2 |
| 46 |
28982942 | Phosphodiesterase-5 inhibition preserves exercise-onset vasodilator kinetics when NOS activity is reduced. | 2018 Feb 1 |
6 |
| 47 |
29132113 | Fluorometric detection of protein-ligand engagement: The case of phosphodiesterase5. | 2018 Feb 5 |
3 |
| 48 |
29301746 | Cyclic-GMP-Elevating Agents Suppress Polyposis in ApcMin mice by Targeting the Preneoplastic Epithelium. | 2018 Feb |
1 |
| 49 |
29416006 | PDE5 inhibition eliminates cancer stem cells via induction of PKA signaling. | 2018 Feb 7 |
2 |
| 50 |
29462984 | Mathematical Modelling of Nitric Oxide/Cyclic GMP/Cyclic AMP Signalling in Platelets. | 2018 Feb 19 |
3 |