Title : Neprilysin inhibition for pulmonary arterial hypertension: a randomized, double-blind, placebo-controlled, proof-of-concept trial.

Pub. Date : 2019 May

PMID : 30761523






1 Functional Relationships(s)
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1 In preclinical models, the combination of a PDE5 inhibitor (PDE5i) with a neprilysin inhibitor augments natriuretic peptide bioactivity, promotes cGMP signalling, and reverses the structural and haemodynamic deficits that characterize PAH. Cyclic GMP phosphodiesterase 5A Homo sapiens