Title : Synaptic and memory dysfunction induced by tau oligomers is rescued by up-regulation of the nitric oxide cascade.

Pub. Date : 2019 Jun 27

PMID : 31248451






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Pharmacological inhibition of cGMP degradation through inhibition of phosphodiesterase 5 (PDE5), rescued oTau-induced LTP reduction. Cyclic GMP phosphodiesterase 5A Homo sapiens
2 Pharmacological inhibition of cGMP degradation through inhibition of phosphodiesterase 5 (PDE5), rescued oTau-induced LTP reduction. Cyclic GMP phosphodiesterase 5A Homo sapiens
3 Finally, PDE5 inhibition re-established normal elevation of CREB phosphorylation and cGMP levels after memory induction in the presence of oTau. Cyclic GMP phosphodiesterase 5A Homo sapiens