Pub. Date : 2020 Mar 28
PMID : 32231130
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Burn-Induced Cardiac Mitochondrial Dysfunction via Interruption of the PDE5A-cGMP-PKG Pathway. | Cyclic GMP | phosphodiesterase 5A | Homo sapiens |
| 2 | This study sought to understand whether burn-induced heart dysfunction is associated with cardiac mitochondrial dysfunction and interruption of the PDE5A-cGMP-PKG pathway. | Cyclic GMP | phosphodiesterase 5A | Homo sapiens |
| 3 | Sildenafil, a inhibitor of the PDE5A-cGMP-PKG pathway, preserved the mitochondrial structure, respiratory chain efficiency and energy status in cardiac tissue. | Cyclic GMP | phosphodiesterase 5A | Homo sapiens |
| 4 | In conclusion, cardiac mitochondrial damage contributes to burn-induced heart dysfunction via the PDE5A-cGMP-PKG pathway. | Cyclic GMP | phosphodiesterase 5A | Homo sapiens |