| 1 |
34310951 | CLEC12B Decreases Melanoma Proliferation by Repressing Signal Transducer and Activator of Transcription 3. | 2022 Feb |
1 |
| 2 |
35154156 | The Inhibitory Receptor Siglec-8 Interacts With FcεRI and Globally Inhibits Intracellular Signaling in Primary Mast Cells Upon Activation. | 2022 |
1 |
| 3 |
35439551 | The down-regulation of tyrosine phosphatase SHP2 activity is involved in the removal of surface AMPA receptors in long term depression. | 2022 May 14 |
2 |
| 4 |
33413561 | PD-1 blockade delays tumor growth by inhibiting an intrinsic SHP2/Ras/MAPK signalling in thyroid cancer cells. | 2021 Jan 7 |
1 |
| 5 |
33562835 | Polyphyllin D Shows Anticancer Effect through a Selective Inhibition of Src Homology Region 2-Containing Protein Tyrosine Phosphatase-2 (SHP2). | 2021 Feb 5 |
1 |
| 6 |
33582386 | Targeting SHP2 as a therapeutic strategy for inflammatory diseases. | 2021 Mar 15 |
2 |
| 7 |
33727228 | Alterations in the Global Proteome and Phosphoproteome in Third Generation EGFR TKI Resistance Reveal Drug Targets to Circumvent Resistance. | 2021 Jun 1 |
1 |
| 8 |
33732417 | Phosphatase Shp2 regulates biogenesis of small extracellular vesicles by dephosphorylating Syntenin. | 2021 Mar |
1 |
| 9 |
33777680 | A multifunctional cross-validation high-throughput screening protocol enabling the discovery of new SHP2 inhibitors. | 2021 Mar |
3 |
| 10 |
34338914 | Exploring the cause of the dual allosteric targeted inhibition attaching to allosteric sites enhancing SHP2 inhibition. | 2021 Aug 2 |
1 |
| 11 |
31561841 | Regulation of peripheral and central immunity: Understanding the role of Src homology 2 domain-containing tyrosine phosphatases, SHP-1 & SHP-2. | 2020 Jan |
1 |
| 12 |
31784318 | Development and structure-activity relationship study of SHP2 inhibitor containing 3,4,6-trihydroxy-5-oxo-5H-benzo[7]annulene. | 2020 Jan 1 |
2 |
| 13 |
31838080 | Targeting SHP2 as a promising strategy for cancer immunotherapy. | 2020 Feb |
1 |
| 14 |
31953320 | A cellular target engagement assay for the characterization of SHP2 (PTPN11) phosphatase inhibitors. | 2020 Feb 28 |
2 |
| 15 |
31954180 | A new abietane diterpenoid from Ajuga ovalifolia var. calantha induces human lung epithelial A549 cell apoptosis by inhibiting SHP2. | 2020 Mar |
2 |
| 16 |
31978797 | Shp2 activation in bone marrow microenvironment mediates the drug resistance of B-cell acute lymphoblastic leukemia through enhancing the role of VCAM-1/VLA-4. | 2020 Mar |
2 |
| 17 |
32024694 | A specific amino acid context in EGFR and HER2 phosphorylation sites enables selective binding to the active site of Src homology phosphatase 2 (SHP2). | 2020 Mar 13 |
2 |
| 18 |
32061959 | Therapeutic potential of targeting SHP2 in human developmental disorders and cancers. | 2020 Mar 15 |
2 |
| 19 |
32076487 | Resistance to allosteric SHP2 inhibition in FGFR-driven cancers through rapid feedback activation of FGFR. | 2020 Jan 21 |
1 |
| 20 |
32236803 | 1H, 13C, 15N chemical shift assignments of SHP2 SH2 domains in complex with PD-1 immune-tyrosine motifs. | 2020 Oct |
3 |
| 21 |
32363035 | SHP2-Independent Tyrosine Dephosphorylation of Cortactin and Vinculin during Infection with Helicobacter pylori. | 2020 Apr 7 |
1 |
| 22 |
32391629 | Blocking interaction between SHP2 and PD-1 denotes a novel opportunity for developing PD-1 inhibitors. | 2020 Jun 8 |
1 |
| 23 |
32460492 | Recent Advances of SHP2 Inhibitors in Cancer Therapy: Current Development and Clinical Application. | 2020 Oct 22 |
3 |
| 24 |
32467571 | Loss of tyrosine phosphatase SHP2 activity promotes growth of colorectal carcinoma HCT-116 cells. | 2020 May 29 |
1 |
| 25 |
32545165 | Understanding the Mechanism of Recognition of Gab2 by the N-SH2 Domain of SHP2. | 2020 Jun 11 |
1 |
| 26 |
32765928 | LEOPARD Syndrome with PTPN11 Gene Mutation in Three Family Members Presenting with Different Phenotypes. | 2020 Dec |
1 |
| 27 |
32910655 | Identification of TNO155, an Allosteric SHP2 Inhibitor for the Treatment of Cancer. | 2020 Nov 25 |
2 |
| 28 |
32921395 | Phosphatase-independent functions of SHP2 and its regulation by small molecule compounds. | 2020 Nov |
2 |
| 29 |
33002410 | Phase Separation of Disease-Associated SHP2 Mutants Underlies MAPK Hyperactivation. | 2020 Oct 15 |
2 |
| 30 |
33113413 | Scaffold-based selective SHP2 inhibitors design using core hopping, molecular docking, biological evaluation and molecular simulation. | 2020 Dec |
2 |
| 31 |
30573803 | A tyrosine kinase-activating variant Asn666Ser in PDGFRB causes a progeria-like condition in the severe end of Penttinen syndrome. | 2019 Apr |
1 |
| 32 |
30688462 | Optimization of Fused Bicyclic Allosteric SHP2 Inhibitors. | 2019 Feb 28 |
1 |
| 33 |
30696956 | Src and SHP2 coordinately regulate the dynamics and organization of vimentin filaments during cell migration. | 2019 May |
1 |
| 34 |
31184863 | Myristoylation-Dependent Palmitoylation of the Receptor Tyrosine Kinase Adaptor FRS2α. | 2019 Jun 25 |
1 |
| 35 |
31373232 | SHP2 inhibitor specifically suppresses the stemness of KRAS-mutant non-small cell lung cancer cells. | 2019 Dec |
1 |
| 36 |
31562133 | Catalytic dysregulation of SHP2 leading to Noonan syndromes affects platelet signaling and functions. | 2019 Dec 19 |
2 |
| 37 |
31807022 | Gain-Of-Function E76K-Mutant SHP2 Promotes Cell Proliferation, Metastasis, And Tumor Growth In Glioblastoma Through Activation Of The ERK/CREB Pathway. | 2019 |
1 |
| 38 |
28804122 | SHP2 is required for BCR-ABL1-induced hematologic neoplasia. | 2018 Jan |
1 |
| 39 |
29282323 | Affinity purification mass spectrometry analysis of PD-1 uncovers SAP as a new checkpoint inhibitor. | 2018 Jan 16 |
1 |
| 40 |
29408202 | Resolvin D1 blocks H2O2-mediated inhibitory crosstalk between SHP2 and PP2A and suppresses endothelial-monocyte interactions. | 2018 Mar |
1 |
| 41 |
30018082 | Synthetic lethality of TNK2 inhibition in PTPN11-mutant leukemia. | 2018 Jul 17 |
3 |
| 42 |
30047735 | Mechanism of Folding and Binding of the N-Terminal SH2 Domain from SHP2. | 2018 Dec 13 |
1 |
| 43 |
30129165 | Exploring the effect of E76K mutation on SHP2 cause gain-of-function activity by a molecular dynamics study. | 2018 Dec |
8 |
| 44 |
30227954 | Transcriptional Co-activator Functions of YAP and TAZ Are Inversely Regulated by Tyrosine Phosphorylation Status of Parafibromin. | 2018 Mar 23 |
1 |
| 45 |
30333625 | LILRB4 signalling in leukaemia cells mediates T cell suppression and tumour infiltration. | 2018 Oct |
1 |
| 46 |
30374120 | Evaluating the origin and virulence of a Helicobacter pylori cagA-positive strain isolated from a non-human primate. | 2018 Oct 29 |
1 |
| 47 |
27696702 | Distinct roles of immunoreceptor tyrosine-based motifs in immunosuppressive indoleamine 2,3-dioxygenase 1. | 2017 Jan |
1 |
| 48 |
28208810 | Shp2 Plays a Critical Role in IL-6-Induced EMT in Breast Cancer Cells. | 2017 Feb 13 |
3 |
| 49 |
28209599 | Role of SHP2 protein tyrosine phosphatase in SERT inhibition by enteropathogenic E. coli (EPEC). | 2017 May 1 |
3 |
| 50 |
28332308 | CEACAM1 long isoform has opposite effects on the growth of human mastocytosis and medullary thyroid carcinoma cells. | 2017 Apr |
1 |