Title : Affinity purification mass spectrometry analysis of PD-1 uncovers SAP as a new checkpoint inhibitor.

Pub. Date : 2018 Jan 16

PMID : 29282323






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Mechanistically, SAP opposed PD-1 function by acting as a molecular shield of key tyrosine residues that are targets for the tyrosine phosphatase SHP2, which mediates PD-1 inhibitory properties. Tyrosine protein tyrosine phosphatase non-receptor type 11 Homo sapiens