Pub. Date : 2020 Oct
PMID : 32236803
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | 1H, 13C, 15N chemical shift assignments of SHP2 SH2 domains in complex with PD-1 immune-tyrosine motifs. | Tyrosine | protein tyrosine phosphatase non-receptor type 11 | Homo sapiens |
| 2 | Activation of PD-1 leads to phosphorylation of two signaling motifs located in its cytoplasmic domain, the immune tyrosine inhibitory motif (ITIM) and immune tyrosine switch motif (ITSM), which recruit and activate protein tyrosine phosphatase SHP2. | Tyrosine | protein tyrosine phosphatase non-receptor type 11 | Homo sapiens |
| 3 | Activation of PD-1 leads to phosphorylation of two signaling motifs located in its cytoplasmic domain, the immune tyrosine inhibitory motif (ITIM) and immune tyrosine switch motif (ITSM), which recruit and activate protein tyrosine phosphatase SHP2. | Tyrosine | protein tyrosine phosphatase non-receptor type 11 | Homo sapiens |