Title : A multifunctional cross-validation high-throughput screening protocol enabling the discovery of new SHP2 inhibitors.

Pub. Date : 2021 Mar

PMID : 33777680






3 Functional Relationships(s)
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1 The established method can effectively exclude the false positive SHP2 inhibitors with fluorescence interference and was also successfully employed to identify new protein tyrosine phosphatase domain of SHP2 (SHP2-PTP) and allosteric inhibitors. Tyrosine protein tyrosine phosphatase non-receptor type 11 Homo sapiens
2 The established method can effectively exclude the false positive SHP2 inhibitors with fluorescence interference and was also successfully employed to identify new protein tyrosine phosphatase domain of SHP2 (SHP2-PTP) and allosteric inhibitors. Tyrosine protein tyrosine phosphatase non-receptor type 11 Homo sapiens
3 The established method can effectively exclude the false positive SHP2 inhibitors with fluorescence interference and was also successfully employed to identify new protein tyrosine phosphatase domain of SHP2 (SHP2-PTP) and allosteric inhibitors. Tyrosine protein tyrosine phosphatase non-receptor type 11 Homo sapiens