Title : Phosphatase Shp2 regulates biogenesis of small extracellular vesicles by dephosphorylating Syntenin.

Pub. Date : 2021 Mar

PMID : 33732417






1 Functional Relationships(s)
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1 By Co-immunoprecipitation (Co-IP) and in vitro dephosphorylation assays, we identified that Shp2 negatively controlled sEV biogenesis by directly dephosphorylating tyrosine 46 of Syntenin, which has been reported as a molecular switch in sEV biogenesis. Tyrosine protein tyrosine phosphatase non-receptor type 11 Homo sapiens