Title : Distinct roles of immunoreceptor tyrosine-based motifs in immunosuppressive indoleamine 2,3-dioxygenase 1.

Pub. Date : 2017 Jan

PMID : 27696702






1 Functional Relationships(s)
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1 However, IDO1 also harbours immunoreceptor tyrosine-based inhibitory motifs, (ITIM1 and ITIM2), that, once phosphorylated, bind protein tyrosine phosphatases, (SHP-1 and SHP-2), and thus trigger an immunoregulatory signalling in DCs. Tyrosine protein tyrosine phosphatase non-receptor type 11 Homo sapiens