Pub. Date : 2021 Jan-Dec
PMID : 34238029
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Metformin Antagonizes Ovarian Cancer Cells Malignancy Through MSLN Mediated IL-6/STAT3 Signaling. | Metformin | signal transducer and activator of transcription 3 | Homo sapiens |
| 2 | On mechanism, metformin treatment remarkably reduced mesothelin (MSLN) expression, downregulated IL-6/STAT3 signaling activity, subsequently resulted in VEGF and TGFbeta1 expression. | Metformin | signal transducer and activator of transcription 3 | Homo sapiens |
| 3 | CONCLUSIONS: Collectively, our findings suggested that metformin exerts anticancer effects by suppressing ovarian cancer cell malignancy, which attributed to MSLN inhibition mediated IL6/STAT3 signaling and VEGF and TGFbeta1 downregulation. | Metformin | signal transducer and activator of transcription 3 | Homo sapiens |