Title : Metformin promotes autophagy and apoptosis in esophageal squamous cell carcinoma by downregulating Stat3 signaling.

Pub. Date : 2014 Feb 27

PMID : 24577086






7 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Metformin promotes autophagy and apoptosis in esophageal squamous cell carcinoma by downregulating Stat3 signaling. Metformin signal transducer and activator of transcription 3 Homo sapiens
2 Mechanistically, signal transducer and activator of transcription 3 (Stat3) and its downstream target Bcl-2 was inactivated by metformin treatment. Metformin signal transducer and activator of transcription 3 Homo sapiens
3 Mechanistically, signal transducer and activator of transcription 3 (Stat3) and its downstream target Bcl-2 was inactivated by metformin treatment. Metformin signal transducer and activator of transcription 3 Homo sapiens
4 Accordingly, small interfering RNA (siRNA)-mediated Stat3 knockdown enhanced metformin-induced autophagy and apoptosis, and concomitantly enhanced the inhibitory effect of metformin on cell viability. Metformin signal transducer and activator of transcription 3 Homo sapiens
5 Accordingly, small interfering RNA (siRNA)-mediated Stat3 knockdown enhanced metformin-induced autophagy and apoptosis, and concomitantly enhanced the inhibitory effect of metformin on cell viability. Metformin signal transducer and activator of transcription 3 Homo sapiens
6 In vivo, metformin downregulated Stat3 activity and Bcl-2 expression, induced apoptosis and autophagy, and inhibited tumor growth. Metformin signal transducer and activator of transcription 3 Homo sapiens
7 Together, inactivation of Stat3-Bcl-2 pathway contributes to metformin-induced growth inhibition of ESCC by facilitating crosstalk between apoptosis and autophagy. Metformin signal transducer and activator of transcription 3 Homo sapiens