Pub. Date : 2014 Feb 27
PMID : 24577086
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Metformin promotes autophagy and apoptosis in esophageal squamous cell carcinoma by downregulating Stat3 signaling. | Metformin | signal transducer and activator of transcription 3 | Homo sapiens |
| 2 | Mechanistically, signal transducer and activator of transcription 3 (Stat3) and its downstream target Bcl-2 was inactivated by metformin treatment. | Metformin | signal transducer and activator of transcription 3 | Homo sapiens |
| 3 | Mechanistically, signal transducer and activator of transcription 3 (Stat3) and its downstream target Bcl-2 was inactivated by metformin treatment. | Metformin | signal transducer and activator of transcription 3 | Homo sapiens |
| 4 | Accordingly, small interfering RNA (siRNA)-mediated Stat3 knockdown enhanced metformin-induced autophagy and apoptosis, and concomitantly enhanced the inhibitory effect of metformin on cell viability. | Metformin | signal transducer and activator of transcription 3 | Homo sapiens |
| 5 | Accordingly, small interfering RNA (siRNA)-mediated Stat3 knockdown enhanced metformin-induced autophagy and apoptosis, and concomitantly enhanced the inhibitory effect of metformin on cell viability. | Metformin | signal transducer and activator of transcription 3 | Homo sapiens |
| 6 | In vivo, metformin downregulated Stat3 activity and Bcl-2 expression, induced apoptosis and autophagy, and inhibited tumor growth. | Metformin | signal transducer and activator of transcription 3 | Homo sapiens |
| 7 | Together, inactivation of Stat3-Bcl-2 pathway contributes to metformin-induced growth inhibition of ESCC by facilitating crosstalk between apoptosis and autophagy. | Metformin | signal transducer and activator of transcription 3 | Homo sapiens |