Title : Metformin selectively targets tumor-initiating cells in ErbB2-overexpressing breast cancer models.

Pub. Date : 2014 Feb

PMID : 24322659






1 Functional Relationships(s)
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1 Molecular analysis indicated that metformin induced downregulation of ErbB2 and EGFR expression and inhibited the phosphorylation of ErbB family members, insulin-like growth factor-1R, AKT, mTOR, and STAT3 in vivo. Metformin signal transducer and activator of transcription 3 Homo sapiens