Pub. Date : 2017
PMID : 28114390
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | High Glucose-Mediated STAT3 Activation in Endometrial Cancer Is Inhibited by Metformin: Therapeutic Implications for Endometrial Cancer. | Metformin | signal transducer and activator of transcription 3 | Homo sapiens |
| 2 | We therefore investigated whether glucose concentrations influence STAT3 expression in type 1 endometrial cancer, and whether such STAT3 expression might be inhibited by metformin. | Metformin | signal transducer and activator of transcription 3 | Homo sapiens |
| 3 | Metformin reduced expression levels of pSTAT3 ser727, total STAT3, and its associated cell survival and anti-apoptotic proteins. | Metformin | signal transducer and activator of transcription 3 | Homo sapiens |
| 4 | In vivo, metformin treatment led to a decrease in tumor weight as well as reductions of STAT3, pSTAT3 ser727, its target proteins. | Metformin | signal transducer and activator of transcription 3 | Homo sapiens |
| 5 | CONCLUSIONS: These results suggest that STAT3 expression in type 1 endometrial cancer is stimulated by a high glucose environment and inhibited by metformin. | Metformin | signal transducer and activator of transcription 3 | Homo sapiens |