PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34887262-15 2021 CONCLUSION: We show that SN-38 or metformin can boost antitumor immunity in the TME by inhibiting c-Myc and STAT3 through FOXO3 activation. Metformin 34-43 signal transducer and activator of transcription 3 Homo sapiens 108-113 34881181-7 2021 PD-L1 expression in ESCC cell lines was significantly inhibited by metformin via the IL-6/JAK2/STAT3 signaling pathway but was not correlated with the canonical AMPK pathway. Metformin 67-76 signal transducer and activator of transcription 3 Homo sapiens 95-100 34881181-10 2021 Conclusions: Metformin downregulated PD-L1 expression by blocking the IL-6/JAK2/STAT3 signaling pathway in ESCC, which enhanced the antitumor immune response. Metformin 13-22 signal transducer and activator of transcription 3 Homo sapiens 80-85 34238029-0 2021 Metformin Antagonizes Ovarian Cancer Cells Malignancy Through MSLN Mediated IL-6/STAT3 Signaling. Metformin 0-9 signal transducer and activator of transcription 3 Homo sapiens 81-86 34302119-0 2021 Correction: Repurposing dextromethorphan and metformin for treating nicotine-induced cancer by directly targeting CHRNA7 to inhibit JAK2/STAT3/SOX2 signaling. Metformin 45-54 signal transducer and activator of transcription 3 Homo sapiens 137-142 34154617-0 2021 Correction to: Metformin ameliorates scleroderma via inhibiting Th17 cells and reducing mTOR-STAT3 signaling in skin fibroblasts. Metformin 15-24 signal transducer and activator of transcription 3 Homo sapiens 93-98 34238029-8 2021 On mechanism, metformin treatment remarkably reduced mesothelin (MSLN) expression, downregulated IL-6/STAT3 signaling activity, subsequently resulted in VEGF and TGFbeta1 expression. Metformin 14-23 signal transducer and activator of transcription 3 Homo sapiens 102-107 34238029-10 2021 CONCLUSIONS: Collectively, our findings suggested that metformin exerts anticancer effects by suppressing ovarian cancer cell malignancy, which attributed to MSLN inhibition mediated IL6/STAT3 signaling and VEGF and TGFbeta1 downregulation. Metformin 55-64 signal transducer and activator of transcription 3 Homo sapiens 187-192 35550195-9 2022 Signal transduction analysis of the paired cell lines indicated that c-Met-induced activation of STAT3 and AKT1, and upregulation of Gab1 are related to c-Met-modulated metformin responsiveness. Metformin 169-178 signal transducer and activator of transcription 3 Homo sapiens 97-102 32791889-13 2021 Metformin treatment decreased the FRO- or SW1736-CM-induced STAT3 phosphorylation by AMPK phosphorylation. Metformin 0-9 signal transducer and activator of transcription 3 Homo sapiens 60-65 35072253-4 2022 The mechanism of the antitumor action of metformin is pleiotropic and involves several signalling pathways, including AMPK/mTOR (mitogen activated protein kinase/mammalian target rapamycin), STAT3 (signal transducer and activator of transcription) and numerous factors: NF-KB (nuclear factor kappa), HIF-1 alpha (hypoxia inducible factor 1), IGF-1 (insulin-like growth factor-1), which affect cell proliferation and apoptosis. Metformin 41-50 signal transducer and activator of transcription 3 Homo sapiens 191-196 33262823-0 2021 Metformin inhibits epithelial-mesenchymal transition of oral squamous cell carcinoma via the mTOR/HIF-1alpha/PKM2/STAT3 pathway. Metformin 0-9 signal transducer and activator of transcription 3 Homo sapiens 114-119 33603170-0 2021 Repurposing dextromethorphan and metformin for treating nicotine-induced cancer by directly targeting CHRNA7 to inhibit JAK2/STAT3/SOX2 signaling. Metformin 33-42 signal transducer and activator of transcription 3 Homo sapiens 125-130 33262823-9 2021 Moreover, metformin reversed EMT in OSCC by inhibiting the mTOR-associated HIF-1alpha/PKM2/STAT3 signaling pathway. Metformin 10-19 signal transducer and activator of transcription 3 Homo sapiens 91-96 33126079-4 2020 In addition, activation of AMPK by metformin inhibited S1P-induced ASMCs proliferation by suppressing STAT3 phosphorylation and therefore suppression of PLK1 and ID2 protein expression. Metformin 35-44 signal transducer and activator of transcription 3 Homo sapiens 102-107 32674107-8 2021 RESULTS: Combination treatment with LMT-28 and metformin diminished proliferation of MH7A cells and IL-6-mediated gp130, STAT3, and ERK signaling more than in individual treatments. Metformin 47-56 signal transducer and activator of transcription 3 Homo sapiens 121-126 31278880-9 2019 Therefore, metformin and phenformin may represent a novel strategy for the treatment of chemoresistant rectal cancer by targeting signal transducer and activator of transcription 3 and transforming growth factor-beta/Smad signaling. Metformin 11-20 signal transducer and activator of transcription 3 Homo sapiens 130-180 33149616-0 2020 Metformin Combined with 4SC-202 Inhibited the Migration and Invasion of OSCC via STAT3/TWIST1. Metformin 0-9 signal transducer and activator of transcription 3 Homo sapiens 81-86 33149616-9 2020 In addition, the phosphorylation level of STAT3 decreased after the administration of metformin or/and 4SC-202. Metformin 86-95 signal transducer and activator of transcription 3 Homo sapiens 42-47 33149616-11 2020 Conclusion: Metformin and 4SC-202 suppressed the invasion and migration of OSCC through inhibition of STAT3/TWIST1, and this scheme can serve as a novel therapeutic strategy for OSCC. Metformin 12-21 signal transducer and activator of transcription 3 Homo sapiens 102-107 33116117-8 2020 Metformin significantly modulated the profiles of the SASP elicited by LY2835219 by inhibiting the mTOR and stat3 pathways. Metformin 0-9 signal transducer and activator of transcription 3 Homo sapiens 108-113 32460059-3 2020 The results indicated that metformin suppressed the in vitro growth of four leukemia cell lines, OCI/AML2, OCI/AML3, THP-1, and K562, in a dose-dependent manner, which corresponded to the downregulation of the expression and phosphorylation of AXL and inhibition of its downstream targets such as phosphorylation of STAT3. Metformin 27-36 signal transducer and activator of transcription 3 Homo sapiens 316-321 32258099-12 2020 Further study revealed that metformin may attenuate the phosphorylation of the Stat3 and the Bcl-2 expression, which was restored by IL-6 partly in EC109 cells but not HEECs. Metformin 28-37 signal transducer and activator of transcription 3 Homo sapiens 79-84 32258099-15 2020 Therefore, the Stat3/Bcl-2 pathway-mediated apoptosis underlies the cell-type-specific drug sensitivity, suggesting metformin possesses a therapeutic activity and selectivity on esophageal cancer. Metformin 116-125 signal transducer and activator of transcription 3 Homo sapiens 15-20 33116117-10 2020 Furthermore, results showed that the stemness inhibition by metformin was associated with blockade of the IL6-stat3 axis. Metformin 60-69 signal transducer and activator of transcription 3 Homo sapiens 110-115 32470453-7 2020 Subsequently, overwhelming evidence showed that both metformin and aspirin can ameliorate T-cell mediated inflammation by inducing regulatory T-cells (Tregs) polarisation, inhibiting T-cell trafficking and activation as well as signal transducer and activator of transcription (STAT)3 signalling. Metformin 53-62 signal transducer and activator of transcription 3 Homo sapiens 228-284 31337349-0 2019 Metformin reverses mesenchymal phenotype of primary breast cancer cells through STAT3/NF-kappaB pathways. Metformin 0-9 signal transducer and activator of transcription 3 Homo sapiens 80-85 31154939-15 2019 Metformin treatment decreased inflammation, IL-6 levels, STAT3 activation, and human PA smooth muscle cell proliferation. Metformin 0-9 signal transducer and activator of transcription 3 Homo sapiens 57-62 31337349-14 2019 CONCLUSION: These results suggest that MTF inhibits IL-6-induced EMT, cell proliferation, and migration of primary breast cancer cells by preventing the activation of STAT3 and NF-kappaB. Metformin 39-42 signal transducer and activator of transcription 3 Homo sapiens 167-172 29472557-6 2018 Metformin reduced cyclin D1 expression and RB, STAT3, STAT5, ERK1/2 and p70S6K phosphorylation. Metformin 0-9 signal transducer and activator of transcription 3 Homo sapiens 47-52 30019648-9 2019 Metformin is AMPK activators that can suppress mTOR, STAT3 and HIF-1 so AMPK activation plays important role in suppressing inflammation and osteoclastogenesis and decreasing cancer. Metformin 0-9 signal transducer and activator of transcription 3 Homo sapiens 53-58 28043910-0 2017 Metformin inhibits castration-induced EMT in prostate cancer by repressing COX2/PGE2/STAT3 axis. Metformin 0-9 signal transducer and activator of transcription 3 Homo sapiens 85-90 28837141-0 2017 Metformin reverses prostate cancer resistance to enzalutamide by targeting TGF-beta1/STAT3 axis-regulated EMT. Metformin 0-9 signal transducer and activator of transcription 3 Homo sapiens 85-90 28837141-6 2017 Furthermore, based on the effect of metformin on the activation of STAT3 and expression of TGF-beta1, we propose that metformin exerts its effects by targeting the TGF-beta1/STAT3 axis. Metformin 36-45 signal transducer and activator of transcription 3 Homo sapiens 67-72 28837141-6 2017 Furthermore, based on the effect of metformin on the activation of STAT3 and expression of TGF-beta1, we propose that metformin exerts its effects by targeting the TGF-beta1/STAT3 axis. Metformin 36-45 signal transducer and activator of transcription 3 Homo sapiens 174-179 28837141-6 2017 Furthermore, based on the effect of metformin on the activation of STAT3 and expression of TGF-beta1, we propose that metformin exerts its effects by targeting the TGF-beta1/STAT3 axis. Metformin 118-127 signal transducer and activator of transcription 3 Homo sapiens 67-72 28837141-6 2017 Furthermore, based on the effect of metformin on the activation of STAT3 and expression of TGF-beta1, we propose that metformin exerts its effects by targeting the TGF-beta1/STAT3 axis. Metformin 118-127 signal transducer and activator of transcription 3 Homo sapiens 174-179 28823275-5 2017 CONCLUSION: Metformin can inhibit the proliferation and induce apoptosis of RPMI8226 and U266 cell lines, which may be related to down-regulation of STAT3 signal transduction pathway. Metformin 12-21 signal transducer and activator of transcription 3 Homo sapiens 149-154 28445726-6 2017 In cancer patients, the SIRT1 agonist metformin reduced the frequency of Th17 cells and STAT3 acetylation levels. Metformin 38-47 signal transducer and activator of transcription 3 Homo sapiens 88-93 28964970-3 2017 The cytotoxic effect of metformin correlated with intracellular reactive oxygen species reduction, activation of AMPK, the inhibition of pro-survival pathways such as mTOR and STAT3 and the down-regulation of v-FLIP, a latent viral antigen that also plays a pivotal role in PEL cell survival. Metformin 24-33 signal transducer and activator of transcription 3 Homo sapiens 176-181 29088816-0 2017 Metformin inhibits esophageal squamous cell carcinoma-induced angiogenesis by suppressing JAK/STAT3 signaling pathway. Metformin 0-9 signal transducer and activator of transcription 3 Homo sapiens 94-99 29088816-6 2017 More importantly, we investigated the anti-angiogenic effect of metformin, and found that metformin abrogated the ESCC microenvironment-induced transition of NECs toward TECs by inhibiting JAK/STAT3/c-MYC signaling pathway. Metformin 90-99 signal transducer and activator of transcription 3 Homo sapiens 193-198 28043910-5 2017 In addition, we showed the effects of metformin on the expression of genes involved in EMT through repressing the levels of COX2, PGE2 and phosphorylated STAT3. Metformin 38-47 signal transducer and activator of transcription 3 Homo sapiens 154-159 28043910-7 2017 We propose that metformin represses prostate cancer EMT and metastasis through targeting the COX2/PGE2/STAT3 axis. Metformin 16-25 signal transducer and activator of transcription 3 Homo sapiens 103-108 27919027-7 2016 Clinically used AMPK activators metformin and salicylate enhanced the inhibitory phosphorylation of endogenous JAK1 and inhibited STAT3 phosphorylation in primary vascular endothelial cells. Metformin 32-41 signal transducer and activator of transcription 3 Homo sapiens 130-135 28345832-9 2017 Furthermore, metformin exposure resultedin decreased STAT3 activation and down-regulation of anti-apoptotic protein Bcl-2 and Mcl-1 expression. Metformin 13-22 signal transducer and activator of transcription 3 Homo sapiens 53-58 28345832-11 2017 Conclusion:These results demonstrated inhibitory effects of metformin on CCA cell migration and invasion, possibly involvingthe STAT3 pathway and reversal of EMT markers expression. Metformin 60-69 signal transducer and activator of transcription 3 Homo sapiens 128-133 28114390-2 2017 We therefore investigated whether glucose concentrations influence STAT3 expression in type 1 endometrial cancer, and whether such STAT3 expression might be inhibited by metformin. Metformin 170-179 signal transducer and activator of transcription 3 Homo sapiens 131-136 28114390-9 2017 Metformin reduced expression levels of pSTAT3 ser727, total STAT3, and its associated cell survival and anti-apoptotic proteins. Metformin 0-9 signal transducer and activator of transcription 3 Homo sapiens 40-45 28114390-12 2017 In vivo, metformin treatment led to a decrease in tumor weight as well as reductions of STAT3, pSTAT3 ser727, its target proteins. Metformin 9-18 signal transducer and activator of transcription 3 Homo sapiens 88-93 28114390-13 2017 CONCLUSIONS: These results suggest that STAT3 expression in type 1 endometrial cancer is stimulated by a high glucose environment and inhibited by metformin. Metformin 147-156 signal transducer and activator of transcription 3 Homo sapiens 40-45 28011481-0 2017 Metformin Exerts Antiproliferative and Anti-metastatic Effects Against Cholangiocarcinoma Cells by Targeting STAT3 and NF-kB. Metformin 0-9 signal transducer and activator of transcription 3 Homo sapiens 109-114 28030813-0 2017 Stattic and metformin inhibit brain tumor initiating cells by reducing STAT3-phosphorylation. Metformin 12-21 signal transducer and activator of transcription 3 Homo sapiens 71-76 28030813-4 2017 Evidence from other tumor models suggests that metformin inhibits STAT3, but there is no specific data on brain tumor initiating cells (BTICs).We explored proliferation and migration of 7 BTICs and their differentiated counterparts (TCs) after treatment with Stattic, metformin or the combination thereof. Metformin 47-56 signal transducer and activator of transcription 3 Homo sapiens 66-71 28030813-9 2017 Treatment with metformin reduced STAT3-phosphorylation in all investigated BTICs and TCs. Metformin 15-24 signal transducer and activator of transcription 3 Homo sapiens 33-38 28030813-12 2017 Stable STAT3 knock-in partly attenuated the effects of Stattic and metformin on BTICs.In conclusion, metformin was found to inhibit STAT3-phosphorylation in BTICs and TCs. Metformin 67-76 signal transducer and activator of transcription 3 Homo sapiens 7-12 28030813-12 2017 Stable STAT3 knock-in partly attenuated the effects of Stattic and metformin on BTICs.In conclusion, metformin was found to inhibit STAT3-phosphorylation in BTICs and TCs. Metformin 67-76 signal transducer and activator of transcription 3 Homo sapiens 132-137 28030813-12 2017 Stable STAT3 knock-in partly attenuated the effects of Stattic and metformin on BTICs.In conclusion, metformin was found to inhibit STAT3-phosphorylation in BTICs and TCs. Metformin 101-110 signal transducer and activator of transcription 3 Homo sapiens 7-12 28030813-12 2017 Stable STAT3 knock-in partly attenuated the effects of Stattic and metformin on BTICs.In conclusion, metformin was found to inhibit STAT3-phosphorylation in BTICs and TCs. Metformin 101-110 signal transducer and activator of transcription 3 Homo sapiens 132-137 28114390-0 2017 High Glucose-Mediated STAT3 Activation in Endometrial Cancer Is Inhibited by Metformin: Therapeutic Implications for Endometrial Cancer. Metformin 77-86 signal transducer and activator of transcription 3 Homo sapiens 22-27 29073599-0 2017 Combination of Solamargine and Metformin Strengthens IGFBP1 Gene Expression Through Inactivation of Stat3 and Reciprocal Interaction Between FOXO3a and SP1. Metformin 31-40 signal transducer and activator of transcription 3 Homo sapiens 100-105 27126953-7 2016 The enhanced signal transducer and activator of transcription 3 activation noted during the development of aGVHD was reduced by metformin treatment. Metformin 128-137 signal transducer and activator of transcription 3 Homo sapiens 13-63 27126953-9 2016 The reduction in mortality associated with metformin treatment was associated with inhibition of the mammalian target of rapamycin/signal transducer and activator of transcription 3 pathway. Metformin 43-52 signal transducer and activator of transcription 3 Homo sapiens 131-181 26360050-0 2015 Metformin Ameliorates Inflammatory Bowel Disease by Suppression of the STAT3 Signaling Pathway and Regulation of the between Th17/Treg Balance. Metformin 0-9 signal transducer and activator of transcription 3 Homo sapiens 71-76 27126953-0 2016 Metformin attenuates graft-versus-host disease via restricting mammalian target of rapamycin/signal transducer and activator of transcription 3 and promoting adenosine monophosphate-activated protein kinase-autophagy for the balance between T helper 17 and Tregs. Metformin 0-9 signal transducer and activator of transcription 3 Homo sapiens 93-143 26641266-12 2015 These effects on macrophages in vitro appear to be associated with a modulation of the AMPK/STAT3 pathway by metformin. Metformin 109-118 signal transducer and activator of transcription 3 Homo sapiens 92-97 26360050-9 2015 Treatment with metformin inhibited the expression of interleukin (IL)-17, p-STAT3, and p-mTOR. Metformin 15-24 signal transducer and activator of transcription 3 Homo sapiens 76-81 26360050-12 2015 CONCLUSIONS: Metformin attenuates IBD severity and reduces inflammation through the inhibition of p-STAT3 and IL-17 expression. Metformin 13-22 signal transducer and activator of transcription 3 Homo sapiens 100-105 24577086-0 2014 Metformin promotes autophagy and apoptosis in esophageal squamous cell carcinoma by downregulating Stat3 signaling. Metformin 0-9 signal transducer and activator of transcription 3 Homo sapiens 99-104 26056043-6 2015 Metformin combined with aspirin significantly inhibited the phosphorylation of mTOR and STAT3, and induced apoptosis as measured by caspase-3 and PARP cleavage. Metformin 0-9 signal transducer and activator of transcription 3 Homo sapiens 88-93 25370454-8 2015 The effects of metformin on T cell differentiation were mediated by downregulated STAT3 and STAT4 phosphorylation via the AMP-activated kinase-mammalian target of rapamycin complex 1 pathway. Metformin 15-24 signal transducer and activator of transcription 3 Homo sapiens 82-87 25462562-0 2015 Metformin enhances the anti-adipogenic effects of atorvastatin via modulation of STAT3 and TGF-beta/Smad3 signaling. Metformin 0-9 signal transducer and activator of transcription 3 Homo sapiens 81-86 24577086-8 2014 Mechanistically, signal transducer and activator of transcription 3 (Stat3) and its downstream target Bcl-2 was inactivated by metformin treatment. Metformin 127-136 signal transducer and activator of transcription 3 Homo sapiens 17-67 24577086-8 2014 Mechanistically, signal transducer and activator of transcription 3 (Stat3) and its downstream target Bcl-2 was inactivated by metformin treatment. Metformin 127-136 signal transducer and activator of transcription 3 Homo sapiens 69-74 24577086-9 2014 Accordingly, small interfering RNA (siRNA)-mediated Stat3 knockdown enhanced metformin-induced autophagy and apoptosis, and concomitantly enhanced the inhibitory effect of metformin on cell viability. Metformin 77-86 signal transducer and activator of transcription 3 Homo sapiens 52-57 24577086-9 2014 Accordingly, small interfering RNA (siRNA)-mediated Stat3 knockdown enhanced metformin-induced autophagy and apoptosis, and concomitantly enhanced the inhibitory effect of metformin on cell viability. Metformin 172-181 signal transducer and activator of transcription 3 Homo sapiens 52-57 24577086-12 2014 In vivo, metformin downregulated Stat3 activity and Bcl-2 expression, induced apoptosis and autophagy, and inhibited tumor growth. Metformin 9-18 signal transducer and activator of transcription 3 Homo sapiens 33-38 24577086-13 2014 Together, inactivation of Stat3-Bcl-2 pathway contributes to metformin-induced growth inhibition of ESCC by facilitating crosstalk between apoptosis and autophagy. Metformin 61-70 signal transducer and activator of transcription 3 Homo sapiens 26-31 23526220-0 2013 Metformin enhances cisplatin cytotoxicity by suppressing signal transducer and activator of transcription-3 activity independently of the liver kinase B1-AMP-activated protein kinase pathway. Metformin 0-9 signal transducer and activator of transcription 3 Homo sapiens 57-107 24322659-8 2014 Molecular analysis indicated that metformin induced downregulation of ErbB2 and EGFR expression and inhibited the phosphorylation of ErbB family members, insulin-like growth factor-1R, AKT, mTOR, and STAT3 in vivo. Metformin 34-43 signal transducer and activator of transcription 3 Homo sapiens 200-205 24302004-7 2014 Activation of AMPK by metformin inhibited mTORC1-STAT3 signaling, thereby preventing excess amino acid-impaired insulin signaling. Metformin 22-31 signal transducer and activator of transcription 3 Homo sapiens 49-54 24302004-9 2014 Chronic administration of either metformin or rapamycin inhibited the HPD-activated mTORC1/STAT3/Notch1 signaling pathway and prevented hepatic insulin resistance. Metformin 33-42 signal transducer and activator of transcription 3 Homo sapiens 91-96 23526220-12 2013 Thus, metformin helps to overcome tumor drug resistance by targeting STAT3. Metformin 6-15 signal transducer and activator of transcription 3 Homo sapiens 69-74 23526220-5 2013 A STAT3 inhibitor (JSI-124) enhanced the cisplatin sensitivity in AS2 cells, whereas metformin inhibited STAT3 phosphorylation and enhanced cisplatin cytotoxicity. Metformin 85-94 signal transducer and activator of transcription 3 Homo sapiens 105-110 23526220-9 2013 Both mechanisms contributed to the ability of metformin to suppress STAT3 activation in cancer cells, which resulted in the decreased secretion of vascular endothelial growth factor by cancer cells. Metformin 46-55 signal transducer and activator of transcription 3 Homo sapiens 68-73 23526220-11 2013 This is the first study to demonstrate that metformin suppresses STAT3 activation via LKB1-AMPK-mTOR-independent but ROS-related and autocrine IL-6 production-related pathways. Metformin 44-53 signal transducer and activator of transcription 3 Homo sapiens 65-70 23162655-7 2012 The action of metformin was mediated through the upregulation of its main signaling molecule, the adenosine monophosphate-activated protein kinase (AMPK), as well as through the downregulation of the signal transducer and activator of transcription 3 (STAT3) and the Akt/PKB serine/threonine protein kinase. Metformin 14-23 signal transducer and activator of transcription 3 Homo sapiens 200-250 23277563-6 2013 Metformin preferentially inhibits nuclear translocation of NF-kappaB and phosphorylation of STAT3 in cancer stem cells compared with non-stem cancer cells in the same population. Metformin 0-9 signal transducer and activator of transcription 3 Homo sapiens 92-97 23162655-7 2012 The action of metformin was mediated through the upregulation of its main signaling molecule, the adenosine monophosphate-activated protein kinase (AMPK), as well as through the downregulation of the signal transducer and activator of transcription 3 (STAT3) and the Akt/PKB serine/threonine protein kinase. Metformin 14-23 signal transducer and activator of transcription 3 Homo sapiens 252-257 22189713-0 2012 Metformin targets Stat3 to inhibit cell growth and induce apoptosis in triple-negative breast cancers. Metformin 0-9 signal transducer and activator of transcription 3 Homo sapiens 18-23 22189713-10 2012 In summary, Stat3 is a critical regulator of metformin action in TN cancer cells, providing the potential for enhancing metformin"s efficacy in the clinical setting. Metformin 120-129 signal transducer and activator of transcription 3 Homo sapiens 12-17 22189713-3 2012 Because TN cells are particularly sensitive to the anti-diabetic agent metformin, we hypothesized that it may target JAK2/Stat3 signaling. Metformin 71-80 signal transducer and activator of transcription 3 Homo sapiens 122-127 22189713-4 2012 The effects of metformin upon Stat3 expression and activation were examined in four human TN cell lines. Metformin 15-24 signal transducer and activator of transcription 3 Homo sapiens 30-35 22189713-6 2012 Metformin inhibited Stat3 activation (P-Stat3) at Tyr705 and Ser727 and downstream signaling in each of the four parental cell lines. Metformin 0-9 signal transducer and activator of transcription 3 Homo sapiens 20-25 22189713-6 2012 Metformin inhibited Stat3 activation (P-Stat3) at Tyr705 and Ser727 and downstream signaling in each of the four parental cell lines. Metformin 0-9 signal transducer and activator of transcription 3 Homo sapiens 40-45 22189713-7 2012 CA-Stat3 transfection attenuated, whereas Stat3 knockdown enhanced, the effects of metformin upon growth inhibition and apoptosis induction. Metformin 83-92 signal transducer and activator of transcription 3 Homo sapiens 3-8 22189713-7 2012 CA-Stat3 transfection attenuated, whereas Stat3 knockdown enhanced, the effects of metformin upon growth inhibition and apoptosis induction. Metformin 83-92 signal transducer and activator of transcription 3 Homo sapiens 42-47 22189713-8 2012 A Stat3 specific inhibitor acted synergistically with metformin in reducing cell growth and inducing apoptosis. Metformin 54-63 signal transducer and activator of transcription 3 Homo sapiens 2-7 22189713-10 2012 In summary, Stat3 is a critical regulator of metformin action in TN cancer cells, providing the potential for enhancing metformin"s efficacy in the clinical setting. Metformin 45-54 signal transducer and activator of transcription 3 Homo sapiens 12-17 21776823-5 2011 Metformin induced apoptosis by arresting cells in G1 phase and reducing cyclin D level and increasing the expression of p21 and cyclin E. Molecular and cellular studies indicated that metformin significantly elevated p53 and Bax levels and reduced STAT3 and Bcl-2. Metformin 0-9 signal transducer and activator of transcription 3 Homo sapiens 248-253 21776823-5 2011 Metformin induced apoptosis by arresting cells in G1 phase and reducing cyclin D level and increasing the expression of p21 and cyclin E. Molecular and cellular studies indicated that metformin significantly elevated p53 and Bax levels and reduced STAT3 and Bcl-2. Metformin 184-193 signal transducer and activator of transcription 3 Homo sapiens 248-253 15236798-6 2004 Thus, it is proposed that metformin--or AMPK---inhibits hepatic CRP production by boosting hepatic nitric oxide synthesis, which in turn impedes Stat3 activation and CRP transcription. Metformin 26-35 signal transducer and activator of transcription 3 Homo sapiens 145-150